Synthesis of 1-O-acyl- and 1-oxo-kamebanin analogues and their cytotoxic activity

Synthesis of 1-O-acyl- and 1-oxo-kamebanin analogues and their cytotoxic activity

[Display omitted] A series of 1-O-acyl- and 1-oxo-kamebanin analogues were prepared from kamebanin, isolated from Rabdosia excisa and their cytotoxicity was assayed on HL60 promyelocytic leukemia cells and HCT116 human colon cancer cells. The structure–activity relationship study showed that the pre...

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Veröffentlicht in:Bioorganic & medicinal chemistry letters 2023-02, Vol.82, p.129149-129149, Article 129149
Hauptverfasser: Aoyagi, Yutaka, Tomita, Kaori, Kobayashi, Asumi, Nakamura, Akari, Fujii, Yuki, Yagi, Momoka, Ichimaru, Yoshimi, Ozawa, Kei, Park, Hyun-Sun, Fukaya, Haruhiko, Yano, Reiko, Hasuda, Tomoyo, Takeya, Koichi, Hitotsuyanagi, Yukio, Gui, Ming-Yu, Jin, Yong-Ri, Li, Xu-Wen
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents - pharmacology
Cytotoxicity
Ent-kaurene
HCT116 Cells
HL-60 Cells
Humans
Isodon
Kamebanin
Semi-synthesis
Structure-Activity Relationship
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Zusammenfassung:[Display omitted] A series of 1-O-acyl- and 1-oxo-kamebanin analogues were prepared from kamebanin, isolated from Rabdosia excisa and their cytotoxicity was assayed on HL60 promyelocytic leukemia cells and HCT116 human colon cancer cells. The structure–activity relationship study showed that the presence of 1-O-acyl groups of a C3–C5 carbon chain increased the cytotoxic activity.
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2023.129149