Impact of the “Zero Resistance” program on acquisition of multidrug-resistant bacteria in patients admitted to Intensive Care Units in Spain. A prospective, intervention, multimodal, multicenter study

To assess the impact of a multimodal interventional project (“Zero Resistance”) on the acquisition of multidrug-resistant bacteria (MDR-B) during the patient’s ICU stay. Prospective, open-label, interventional, multicenter study. 103 ICUs. Critically ill patients admitted to the ICUs over a 27-month period. Implementation of a bundle of 10 recommendations to prevent emergence and spread of MDR-B in the ICU. Rate of patients acquiring MDR-B during their ICU stay, with differentiation between colonization and infection. A total of 139,505 patients were included. In 5409 (3.9%) patients, 6020 MDR-B on ICU admission were identified, and in 3648 (2.6%) patients, 4269 new MDR-B during ICU stay were isolated. The rate of patients with MDR-B detected on admission increased significantly (IRR 1.43, 95% CI 1.31–1.56) (p