A New Lignan (Polonilignan) and Inhibitors of Nitric Oxide Production from Penicillium polonicum, an Endophytic Fungi of Piper nigrum

Inhibiting nitric oxide (NO) or its production is found to be of therapeutic benefit. To discover natural small molecule inhibitors of NO production, a bioassay‐ and LC/MS‐guided chemical investigation was done on the metabolites of endophytic fungus isolated from fresh Piper nigrum fruits. The isol...

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Veröffentlicht in:	Chemistry & biodiversity 2023-03, Vol.20 (3), p.e202200840-n/a
Hauptverfasser:	Pal, Pragya Paramita, Begum, Sajeli A., Basha, Ameer S., Araya, Hiroshi, Fujimoto, Yoshinori
Format:	Artikel
Sprache:	eng
Schlagworte:	Bioassays Carboxylic acids Cell culture Column chromatography Endophytes endophytic fungi Fruits Fungi Inhibitors Lignans Lignans - metabolism Lignans - pharmacology lignin Lipopolysaccharides Lipopolysaccharides - pharmacology Metabolites Nitric oxide Nitric Oxide - metabolism nitric oxide inhibition NMR Nuclear magnetic resonance Penicillium Penicillium - chemistry Penicillium polonicum Peridinium polonicum Piper nigrum Plant Extracts - metabolism polonilignan rRNA 16S Spectral analysis Spectrum analysis Tyrosol
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Zusammenfassung:	Inhibiting nitric oxide (NO) or its production is found to be of therapeutic benefit. To discover natural small molecule inhibitors of NO production, a bioassay‐ and LC/MS‐guided chemical investigation was done on the metabolites of endophytic fungus isolated from fresh Piper nigrum fruits. The isolated pure strain was identified as Penicillium polonicum by 16S rDNA sequence comparison. The culture broth extract of P. polonicum (EEPP) exhibited a significant reduction of NO production (Griess method) in LPS‐stimulated RAW 264.7 cells (P
ISSN:	1612-1872 1612-1880
DOI:	10.1002/cbdv.202200840