Papulonodular pigmented lesions in a patient with Stage IV malignant melanoma

A 78-year-old man received immunotherapy for in-transit metastatic melanoma papulonodules on his left lower abdomen in the form of intralesional injections of talimogene laherparepvec (T-VEC), an oncolytic genetically modified herpes virus. Despite therapy, the colour and size of the lesions remaine...

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Veröffentlicht in:Clinical and experimental dermatology 2023-01, Vol.48 (1), p.57-59
Hauptverfasser: Daruish, Maged, Papa, Sophie, L C Geh, Jenny, M Stefanato, Catherine
Format: Artikel
Sprache:eng
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Zusammenfassung:A 78-year-old man received immunotherapy for in-transit metastatic melanoma papulonodules on his left lower abdomen in the form of intralesional injections of talimogene laherparepvec (T-VEC), an oncolytic genetically modified herpes virus. Despite therapy, the colour and size of the lesions remained clinically unchanged; however, histopathological examination revealed only melanophages in the absence of melanoma cells. The diagnosis of tumoral melanosis secondary to immunotherapy with T-VEC was made. This case emphasizes the importance of histopathological evaluation in assessing response to immunotherapy of in-transit metastatic melanoma lesions.
ISSN:0307-6938
1365-2230
DOI:10.1093/ced/llac002