Closed‐loop oxygen system in late preterm/term, ventilated infants with different severities of respiratory disease

Aim To evaluate closed‐loop automated oxygen control (CLAC) in ventilated infants >33 weeks of gestation with different respiratory disease severities. Methods Infants were studied on two consecutive days for 6 h each day. They were randomised to receive standard care or standard care with CLAC (Oxygenie) first. Analyses were performed of the results of infants with or without an FiO2 ≥ 0.3 and infants with congenital diaphragmatic hernia (CDH). Results Thirty‐one infants with a median (IQR) gestational age of 37.9 (37.1–38.9) weeks were studied at a median postmenstrual age (IQR) of 38.9 (37.4–39.8) weeks. In infants with an FiO2 ≥ 0.3 (n = 8), CLAC increased the time spent in target oxygen range (92–96%) by 61.6% (p = 0.018), whereas in infants with an FiO2 96%) (p = 0.012) and hyperoxemic episodes were shorter (p = 0.012). In both groups, CLAC reduced the duration of desaturations (SpO2