Microbial cellulosic pad encompassing alpha-arbutin in Tragacanth gum as the controlled delivery system
This research focuses on preparing a natural-based drug delivery system for α-arbutin (AR) as a skin lightening. Bacterial cellulose nanofibers (BC) pad was used for controlled-AR release through two approaches. First was the dip-drying method (P-BC), in which AR cross-linked to BC pads using citric...
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Veröffentlicht in: | International journal of biological macromolecules 2023-03, Vol.232, p.123292-123292, Article 123292 |
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Sprache: | eng |
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Zusammenfassung: | This research focuses on preparing a natural-based drug delivery system for α-arbutin (AR) as a skin lightening. Bacterial cellulose nanofibers (BC) pad was used for controlled-AR release through two approaches. First was the dip-drying method (P-BC), in which AR cross-linked to BC pads using citric acid (CA). The second was simultaneously entrapping of AR in Tragacanth gum (AR-TG) and stabilized on BC (BC-T) through the ultrasonic-assisted microemulsion method. UV–Vis spectra revealed better control of AR release in BC-T in the first hour. High cell viability (above 70 %) of the pads containing 1–3 % AR was reported using MTT assay. The in-vitro permeation study indicated the proper AR penetration in the treated pads. The Fickian diffusion model was determined as a fitted model for all pads in the drug release kinetics. FTIR, XRD, and TGA analyses further characterized the pads. FESEM images verified AR-TG and BC structures with average diameters of 410.7 ± 25.4 and 34.5 ± 7.51 nm, respectively. The hydrophilicity and mechanical properties of the pads were also investigated. Finally, the high biocompatibility, initial controlled release, and proper permeation suggested BC-T as a more promising delivery platform for AR.
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•The potentiality of bacterial cellulose for alpha-arbutin delivery•Comparing alpha-arbutin release using dip-dry and microemulsion methods•Studying of kinetics of drug release from bacterial cellulose pad•Convenient skin pads for treating hyperpigmentation disorder•Producing considerable cell viability with controlled drug release |
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ISSN: | 0141-8130 1879-0003 |
DOI: | 10.1016/j.ijbiomac.2023.123292 |