AlCl3-catalyzed chemoselective cascade reactions of 4-anilinocoumarins with 2-furylcarbinols: access to densely functionalized chromeno[4,3-b]pyrrol-4(1H)-one derivatives

An unprecedented protocol has been developed for the preparation of highly functionalized chromeno[4,3-b]pyrrol-4(1H)-ones, which are not only valuable architectures of many biologically active molecules but also key building blocks for rich photophysical properties. The transformation proceeded through chemoselective intermolecular α-carbon nucleophilic attacking/ring-opening/Michael addition/deprotonation aromatization processes from 4-aminocoumarins and 2-furylcarbinols.