Are hemicolectomies justified for appendiceal neuroendocrine tumours smaller than 2 cm?

[...]various guidelines have recommended hemicolectomy for patients meeting consensus-defined risk criteria.6,7 However, other studies have focused on an interesting characteristic of appendiceal NETs: even patients with locoregional lymph node involvement almost never develop metachronous distant m...

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Veröffentlicht in:The lancet oncology 2023-02, Vol.24 (2), p.121-122
Hauptverfasser: Strosberg, Jonathan R, Al-Toubah, Taymeyah
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Sprache:eng
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Zusammenfassung:[...]various guidelines have recommended hemicolectomy for patients meeting consensus-defined risk criteria.6,7 However, other studies have focused on an interesting characteristic of appendiceal NETs: even patients with locoregional lymph node involvement almost never develop metachronous distant metastases. [...]consideration of hemicolectomy in patients with a high risk of nodal involvement who insist on definitive surgical therapy might be reasonable, despite a thorough discussion highlighting no evidence of benefit. In summary, there is strong evidence to support the peculiar reality that regional nodal metastases from appendiceal NETs are clinically insignificant and do not portend distant metastases. [...]the data indicate that right-sided hemicolectomy is not justified for patients with appendiceal NETs of 1–2 cm in size, regardless of pathological risk factors.
ISSN:1470-2045
1474-5488
DOI:10.1016/S1470-2045(22)00764-1