Addressing the genetic/nongenetic duality in cancer with systems biology

Addressing the genetic/nongenetic duality in cancer with systems biology

The dogma that cancer is a genetic disease is being questioned. Recent findings suggest that genetic/nongenetic duality is necessary for cancer progression. A think tank organized by the Shraman Foundation's Institute for Theoretical Biology compiled key challenges and opportunities that theore...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Trends in Cancer 2023-03, Vol.9 (3), p.185-187
Hauptverfasser: Kulkarni, Prakash, Wiley, H Steven, Levine, Herbert, Sauro, Herbert, Anderson, Alexander, Wong, Stephen T C, Meyer, Aaron S, Iyengar, Puneeth, Corlette, Kevin, Swanson, Kristin, Mohanty, Atish, Bhattacharya, Supriyo, Patel, Amit, Jain, Vinay, Salgia, Ravi
Format: Artikel
Sprache:eng
Schlagworte:
Humans
Neoplasms - genetics
Systems Biology
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The dogma that cancer is a genetic disease is being questioned. Recent findings suggest that genetic/nongenetic duality is necessary for cancer progression. A think tank organized by the Shraman Foundation's Institute for Theoretical Biology compiled key challenges and opportunities that theoreticians, experimentalists, and clinicians can explore from a systems biology perspective to provide a better understanding of the disease as well as help discover new treatment options and therapeutic strategies.
ISSN:2405-8033
2405-8025
DOI:10.1016/j.trecan.2022.12.004