Optical coherence tomography angiography findings in transfusion-dependent beta-thalassemia patients with and without splenectomy

•OCTA can provide information about the microvascular effects of splenectomy.•Choriocapillaris flow area may decrease due to splenectomy in TDβ-T patients.•Retinal thicknesses may be thinner in TDβ-T patients. Ocular involvement is common in transfusion-dependent beta-thalassemia (TDβ-T) patients. W...

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Veröffentlicht in:Photodiagnosis and photodynamic therapy 2023-06, Vol.42, p.103282-103282, Article 103282
Hauptverfasser: Koctekin, Belkis, Karakus, Volkan, Dogan, Berna, Erdem, Ramazan, Dogan, Ugur, Buber, Hakan, Kurtoglu, Erdal
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Sprache:eng
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Zusammenfassung:•OCTA can provide information about the microvascular effects of splenectomy.•Choriocapillaris flow area may decrease due to splenectomy in TDβ-T patients.•Retinal thicknesses may be thinner in TDβ-T patients. Ocular involvement is common in transfusion-dependent beta-thalassemia (TDβ-T) patients. We aimed to investigate the effect of splenectomy on optical coherence tomography angiography (OCTA) findings in TDβ-T patients. The study is a prospective cross-sectional study. A total of 45 eyes of 23 patients with splenectomy (34.04±8.83 years), 18 eyes of 9 patients without splenectomy (27.44±5.43 years), and 54 eyes of 27 controls (33.22±6.44 years) were included. Vessel density in superficial capillary plexus, deep capillary plexus and radial peripapillary capillary, foveal avascular zone, choriocapillaris flow area, choroidal and retinal thickness detected by OCTA were evaluated. p 
ISSN:1572-1000
1873-1597
DOI:10.1016/j.pdpdt.2023.103282