Antibody Response to Omicron BA.4–BA.5 Bivalent Booster

Boosting Vaccination with BA.4–BA.5 SequencesIn a small study, a bivalent mRNA vaccine targeting omicron BA.4–BA.5 sublineages resulted in similar neutralization of other SARS-CoV-2 variants as a fourth dose of a monovalent mRNA vaccine.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2023-02, Vol.388 (6), p.567-569
Hauptverfasser:	Wang, Qian, Bowen, Anthony, Valdez, Riccardo, Gherasim, Carmen, Gordon, Aubree, Liu, Lihong, Ho, David D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Neutralizing - immunology Antibodies, Viral - immunology Antibody Formation - immunology Antibody response Coronavirus COVID-19 - immunology COVID-19 - prevention & control COVID-19 - virology Humans Immunization Infections Infectious Disease mRNA mRNA vaccines Severe acute respiratory syndrome coronavirus 2 Vaccines Vaccines, Combined - immunology Vaccines, Combined - therapeutic use Viral Infections
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Beschreibung
Zusammenfassung:	Boosting Vaccination with BA.4–BA.5 SequencesIn a small study, a bivalent mRNA vaccine targeting omicron BA.4–BA.5 sublineages resulted in similar neutralization of other SARS-CoV-2 variants as a fourth dose of a monovalent mRNA vaccine.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMc2213907