Immunogenicity of BA.5 Bivalent mRNA Vaccine Boosters

In a small study, neutralizing antibody titers against the ancestral strain of SARS-CoV-2 were higher than titers against omicron BA.5 after both monovalent and bivalent boosting.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2023-02, Vol.388 (6), p.565-567
Hauptverfasser:	Collier, Ai-ris Y., Miller, Jessica, Hachmann, Nicole P., McMahan, Katherine, Liu, Jinyan, Bondzie, Esther A., Gallup, Lydia, Rowe, Marjorie, Schonberg, Eleanor, Thai, Siline, Barrett, Julia, Borducchi, Erica N., Bouffard, Emily, Jacob-Dolan, Catherine, Mazurek, Camille R., Mutoni, Audrey, Powers, Olivia, Sciacca, Michaela, Surve, Nehalee, VanWyk, Haley, Wu, Cindy, Barouch, Dan H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Neutralizing Antibodies, Viral Coronavirus COVID-19 - genetics COVID-19 - immunology COVID-19 - prevention & control COVID-19 - virology Humans Immunogenicity Immunogenicity, Vaccine - immunology Infections Infectious Disease mRNA mRNA Vaccines Severe acute respiratory syndrome coronavirus 2 Vaccines Vaccines, Combined - immunology Vaccines, Combined - therapeutic use Vaccines, Synthetic - immunology Vaccines, Synthetic - therapeutic use Viral Infections
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Beschreibung
Zusammenfassung:	In a small study, neutralizing antibody titers against the ancestral strain of SARS-CoV-2 were higher than titers against omicron BA.5 after both monovalent and bivalent boosting.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMc2213948