Electricity‐Wettability Controlled Fast Transmission of Dopamine in Nanochannels

Achieving fast transmembrane transmission of molecules in organisms is a challenging problem. Inspired by the transport of Dopmine (DA) in organisms, the DA transporter (DAT) binds to DA in a way that has a ring recognition (the recognition group is the tryptophan group). Herein, D‐Tryptophan‐pillar...

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Veröffentlicht in:Small (Weinheim an der Bergstrasse, Germany) Germany), 2023-04, Vol.19 (15), p.e2205488-n/a
Hauptverfasser: Fang, Yuan, Xu, Weiwei, Yang, Lei, Qu, Haonan, Wang, Wenqian, Zhang, Siyun, Li, Haibing
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Sprache:eng
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Zusammenfassung:Achieving fast transmembrane transmission of molecules in organisms is a challenging problem. Inspired by the transport of Dopmine (DA) in organisms, the DA transporter (DAT) binds to DA in a way that has a ring recognition (the recognition group is the tryptophan group). Herein, D‐Tryptophan‐pillar[5]arene (D‐Trp‐P5) functionalized conical nanochannel is constructed to achieve fast transmission of DA. The D‐Trp‐P5 functionalized nanochannel enables specific wettability recognition of DA molecules and has great cycle stability. With the controlling of voltage to wettability, the transport flux of DA is up to 499.73 nmol cm−2 h−1 at −6 V, 16.88 times higher than that under positive voltages. In response to these results, a high‐throughput DA transport device based on controlled electricity‐wettability is provided. The D‐Tryptophan Pillar[5]arene (D‐Trp‐P5) was into artificial PET conical nanochannels to construct D‐Trp‐P5 functionalized nanochannel membranes. The D‐Trp‐P5 functionalized nanochannels not only realized the wettability recognition of DA, but also realized the electricity‐wettability controlled fast transport of dopamine in the nanochannels.
ISSN:1613-6810
1613-6829
DOI:10.1002/smll.202205488