Association between mitochondria-related genes and cognitive performance in the PsyCourse Study

Mitochondria generate energy through oxidative phosphorylation (OXPHOS). The function of key OXPHOS proteins can be altered by variation in mitochondria-related genes, which may increase the risk of mental illness. We investigated the association of mitochondria-related genes and their genetic risk...

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Veröffentlicht in:	Journal of affective disorders 2023-03, Vol.325, p.1-6
Hauptverfasser:	Oraki Kohshour, Mojtaba, Schulte, Eva C., Heilbronner, Urs, Budde, Monika, Kalman, Janos L., Senner, Fanny, Heilbronner, Maria, Reich-Erkelenz, Daniela, Schaupp, Sabrina K., Vogl, Thomas, Adorjan, Kristina, Anghelescu, Ion-George, Arolt, Volker, Baune, Bernhardt T., Dannlowski, Udo, Dietrich, Detlef, Fallgatter, Andreas, Figge, Christian, Jäger, Markus, Lang, Fabian U., Juckel, Georg, Konrad, Carsten, Reimer, Jens, Reininghaus, Eva Z., Schmauß, Max, Spitzer, Carsten, von Hagen, Martin, Wiltfang, Jens, Zimmermann, Jörg, Andlauer, Till F.M., Nöthen, Markus M., Degenhardt, Franziska, Forstner, Andreas J., Rietschel, Marcella, Witt, Stephanie H., Fischer, Andre, Falkai, Peter, Papiol, Sergi, Schulze, Thomas G.
Format:	Artikel
Sprache:	eng
Schlagworte:	Brain disorders COA8 Cognition Cognitive Dysfunction - complications Cognitive Dysfunction - genetics Cross-Sectional Studies Humans Mitochondria Mitochondria - genetics Neuropsychological Tests Oxidative phosphorylation Schizophrenia - complications Short-term memory
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Zusammenfassung:	Mitochondria generate energy through oxidative phosphorylation (OXPHOS). The function of key OXPHOS proteins can be altered by variation in mitochondria-related genes, which may increase the risk of mental illness. We investigated the association of mitochondria-related genes and their genetic risk burden with cognitive performance. We leveraged cross-sectional data from 1320 individuals with a severe psychiatric disorder and 466 neurotypical individuals from the PsyCourse Study. The cognitive tests analyzed were the Trail-Making Test, Verbal Digit Span Test, Digit-Symbol Test, and Multiple Choice Vocabulary Intelligence Test. Association analyses between the cognitive tests, and single-nucleotide polymorphisms (SNPs) mapped to mitochondria-related genes, and their polygenic risk score (PRS) for schizophrenia (SCZ) were performed with PLINK 1.9 and R program. We found a significant association (FDR-adjusted p
ISSN:	0165-0327 1573-2517
DOI:	10.1016/j.jad.2023.01.013