Susceptibility of Patients with Inflammatory Bowel Disease to COVID-19 Compared with Their Households
: Immunosuppressive agents used in the treatment of inflammatory bowel diseases (IBDs) could potentially increase the risk of coronavirus disease 2019 (COVID-19). We aimed to compare COVID-19 frequency in patients with IBD with their households and identify the related risk factors. : Firstly, a mul...
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Veröffentlicht in: | Middle East Journal of Digestive Diseases 2022-04, Vol.14 (2), p.182-191 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | : Immunosuppressive agents used in the treatment of inflammatory bowel diseases (IBDs) could potentially increase the risk of coronavirus disease 2019 (COVID-19). We aimed to compare COVID-19 frequency in patients with IBD with their households and identify the related risk factors.
: Firstly, a multi-centered, observational study on 2110 patients with IBD and 2110 age-matched household members was conducted to compare COVID-19 frequency. Secondly, the data of patients with IBD and COVID-19 who had called the COVID-19 hotline were added. Multivariable logistic regression was used to evaluate the effect of age, type and severity of IBD, the number of comorbidities, and medications on the frequency of COVID-19 among the patients with IBD.
: The prevalence of COVID-19 in patients with IBD and household groups was similar (34 [1.61%] versus 35 [1.65%];
= 0.995). The prevalence of COVID-19 increased from 2.1% to 7.1% in those with three or more comorbidities (
= 0.015) and it was significantly higher in those with severe IBD (
= 0.026). The multivariable analysis only showed a significant association with anti-TNF monotherapy (OR: 2.5, CI: 0.97-6.71,
= 0.05), and other medications were not associated with COVID-19.
: The prevalence of COVID-19 in patients with IBD was similar to the household members. Only patients with IBD receiving anti-TNF monotherapy had a higher risk of COVID-19 susceptibility. This finding could be attributed to the higher exposure to the virus during administration in health care facilities. |
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ISSN: | 2008-5230 2008-5249 2008-5249 |
DOI: | 10.34172/mejdd.2022.271 |