Effect of nanomicelle curcumin-based photodynamic therapy on the dynamics of white spot lesions and virulence of Streptococcus mutans in patients undergoing fixed orthodontic treatment: A randomized double-blind clinical trial

•The anti-virulence and antimicrobial activities of NMCur-aPDT against S. mutans were higher than the VITIS®.•The mean of WSLs in NMCur-aPDT group was lower than the VITIS® in 90 and 120 days of follow-up.•3-The antimicrobial properties of VITIS® and NMCur-aPDT are time-dependent so the highest effe...

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Veröffentlicht in:	Photodiagnosis and photodynamic therapy 2022-12, Vol.40, p.103183-103183, Article 103183
Hauptverfasser:	Hosseinpour-Nader, Armin, Karimi, Narges, Ghafari, Hassan-Ali, Ghorbanzadeh, Roghayeh
Format:	Artikel
Sprache:	eng
Schlagworte:	Antimicrobial photodynamic therapy Biofilms Curcumin - pharmacology Dental Caries - drug therapy Fixed orthodontic treatment Humans Laser fluorescence scanning Nanomicelle curcumin Photochemotherapy - methods Photosensitizing Agents - pharmacology Photosensitizing Agents - therapeutic use Streptococcus mutans White spot lesions
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Zusammenfassung:	•The anti-virulence and antimicrobial activities of NMCur-aPDT against S. mutans were higher than the VITIS®.•The mean of WSLs in NMCur-aPDT group was lower than the VITIS® in 90 and 120 days of follow-up.•3-The antimicrobial properties of VITIS® and NMCur-aPDT are time-dependent so the highest effects were observed on day 120.•In NMCur-aPDT and VITIS® groups, the mean number of WSLs per patient significantly decreased (P
ISSN:	1572-1000 1873-1597
DOI:	10.1016/j.pdpdt.2022.103183