A PREVENTIVE TOOL FOR PREDICTING BLOODSTREAM INFECTIONS IN CHILDREN WITH BURNS

A PREVENTIVE TOOL FOR PREDICTING BLOODSTREAM INFECTIONS IN CHILDREN WITH BURNS

Introduction: Despite significant advances in pediatric burn care, bloodstream infections (BSIs) remain a compelling challenge during recovery. A personalized medicine approach for accurate prediction of BSIs before they occur would contribute to prevention efforts and improve patient outcomes. Meth...

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Veröffentlicht in:Shock (Augusta, Ga.) Ga.), 2023-03, Vol.59 (3), p.393-399
Hauptverfasser: Tsurumi, Amy, Flaherty, Patrick J., Que, Yok-Ai, Ryan, Colleen M., Banerjee, Ankita, Chakraborty, Arijit, Almpani, Marianna, Shankar, Malavika, Goverman, Jeremy, Schulz, John T., Sheridan, Robert L., Friedstat, Jonathan, Hickey, Sean A., Tompkins, Ronald G., Rahme, Laurence G.
Format: Artikel
Sprache:eng
Schlagworte:
Burns
Child
Humans
Inflammation
Length of Stay
Retrospective Studies
Sepsis
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Zusammenfassung:Introduction: Despite significant advances in pediatric burn care, bloodstream infections (BSIs) remain a compelling challenge during recovery. A personalized medicine approach for accurate prediction of BSIs before they occur would contribute to prevention efforts and improve patient outcomes. Methods: We analyzed the blood transcriptome of severely burned (total burn surface area [TBSA] ≥20%) patients in the multicenter Inflammation and Host Response to Injury ("Glue Grant") cohort. Our study included 82 pediatric (aged
ISSN:1073-2322
1540-0514
DOI:10.1097/SHK.0000000000002075