5-hydroxymethylcytosine stabilizes transcription by preventing aberrant initiation in gene bodies

5-hydroxymethylcytosine (5hmC) accumulates in transcribed gene regions (called ‘gene bodies’) and near enhancers, but its biological role has remained mysterious. A new study demonstrates that 5hmC serves to counteract inappropriate, spurious intragenic transcription in airway smooth muscle cells an...

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Veröffentlicht in:	Nature genetics 2023-01, Vol.55 (1), p.2-3
1. Verfasser:	Pfeifer, Gerd P.
Format:	Artikel
Sprache:	eng
Schlagworte:	5-Methylcytosine 631/337/176 692/699/1785/31 Agriculture Animal Genetics and Genomics Asthma Biomedical and Life Sciences Biomedicine Cancer Research Cytosine Deactivation DNA Methylation - genetics Gene expression Gene Function Gene sequencing Genomes Human Genetics Immune response Immune system Inactivation Inflammation Mammals Muscles News & Views news-and-views Nucleic acids Phenotypes Proteins RNA polymerase Smooth muscle Stem cells TLR7 protein Toll-like receptors Transcription initiation
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