5-hydroxymethylcytosine stabilizes transcription by preventing aberrant initiation in gene bodies

5-hydroxymethylcytosine stabilizes transcription by preventing aberrant initiation in gene bodies

5-hydroxymethylcytosine (5hmC) accumulates in transcribed gene regions (called ‘gene bodies’) and near enhancers, but its biological role has remained mysterious. A new study demonstrates that 5hmC serves to counteract inappropriate, spurious intragenic transcription in airway smooth muscle cells an...

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Veröffentlicht in:Nature genetics 2023-01, Vol.55 (1), p.2-3
1. Verfasser: Pfeifer, Gerd P.
Format: Artikel
Sprache:eng
Schlagworte:
5-Methylcytosine
631/337/176
692/699/1785/31
Agriculture
Animal Genetics and Genomics
Asthma
Biomedical and Life Sciences
Biomedicine
Cancer Research
Cytosine
Deactivation
DNA Methylation - genetics
Gene expression
Gene Function
Gene sequencing
Genomes
Human Genetics
Immune response
Immune system
Inactivation
Inflammation
Mammals
Muscles
News & Views
news-and-views
Nucleic acids
Phenotypes
Proteins
RNA polymerase
Smooth muscle
Stem cells
TLR7 protein
Toll-like receptors
Transcription initiation
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Beschreibung
Zusammenfassung:5-hydroxymethylcytosine (5hmC) accumulates in transcribed gene regions (called ‘gene bodies’) and near enhancers, but its biological role has remained mysterious. A new study demonstrates that 5hmC serves to counteract inappropriate, spurious intragenic transcription in airway smooth muscle cells and by doing so, this DNA base functions in the prevention of chronic inflammation in the lung and an asthma-like phenotype.
ISSN:1061-4036
1546-1718
DOI:10.1038/s41588-022-01253-2