5-hydroxymethylcytosine stabilizes transcription by preventing aberrant initiation in gene bodies
5-hydroxymethylcytosine (5hmC) accumulates in transcribed gene regions (called ‘gene bodies’) and near enhancers, but its biological role has remained mysterious. A new study demonstrates that 5hmC serves to counteract inappropriate, spurious intragenic transcription in airway smooth muscle cells an...
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| Veröffentlicht in: | Nature genetics 2023-01, Vol.55 (1), p.2-3 |
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| creator | Pfeifer, Gerd P. |
| description | 5-hydroxymethylcytosine (5hmC) accumulates in transcribed gene regions (called ‘gene bodies’) and near enhancers, but its biological role has remained mysterious. A new study demonstrates that 5hmC serves to counteract inappropriate, spurious intragenic transcription in airway smooth muscle cells and by doing so, this DNA base functions in the prevention of chronic inflammation in the lung and an asthma-like phenotype. |
| doi_str_mv | 10.1038/s41588-022-01253-2 |
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| subjects | 5-Methylcytosine 631/337/176 692/699/1785/31 Agriculture Animal Genetics and Genomics Asthma Biomedical and Life Sciences Biomedicine Cancer Research Cytosine Deactivation DNA Methylation - genetics Gene expression Gene Function Gene sequencing Genomes Human Genetics Immune response Immune system Inactivation Inflammation Mammals Muscles News & Views news-and-views Nucleic acids Phenotypes Proteins RNA polymerase Smooth muscle Stem cells TLR7 protein Toll-like receptors Transcription initiation |
| title | 5-hydroxymethylcytosine stabilizes transcription by preventing aberrant initiation in gene bodies |
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