Accounting for diversity in the design of CRISPR-based therapeutic genome editing
CRISPR cell and gene therapy have been designed largely with respect to a single reference human genome. A new study reveals how human genetic diversity could lead to off-target effects and presents a new tool to identify these risks.
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| Veröffentlicht in: | Nature genetics 2023-01, Vol.55 (1), p.6-7 |
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| container_title | Nature genetics |
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| creator | Saha, Krishanu |
| description | CRISPR cell and gene therapy have been designed largely with respect to a single reference human genome. A new study reveals how human genetic diversity could lead to off-target effects and presents a new tool to identify these risks. |
| doi_str_mv | 10.1038/s41588-022-01272-z |
| format | Article |
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| subjects | 45/41 631/1647 631/61/201 Agriculture Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Blood diseases Cancer Research Cancer therapies CRISPR CRISPR-Cas Systems - genetics Drug development Editing Editors Gene Editing Gene Function Gene therapy Genetic diversity Genomes Human Genetics Medical research News & Views news-and-views Nucleotide sequence Patients Polymorphism Product design Product safety Product testing Sickle cell disease |
| title | Accounting for diversity in the design of CRISPR-based therapeutic genome editing |
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