Accounting for diversity in the design of CRISPR-based therapeutic genome editing

CRISPR cell and gene therapy have been designed largely with respect to a single reference human genome. A new study reveals how human genetic diversity could lead to off-target effects and presents a new tool to identify these risks.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature genetics 2023-01, Vol.55 (1), p.6-7
1. Verfasser:	Saha, Krishanu
Format:	Artikel
Sprache:	eng
Schlagworte:	45/41 631/1647 631/61/201 Agriculture Animal Genetics and Genomics Biomedical and Life Sciences Biomedicine Blood diseases Cancer Research Cancer therapies CRISPR CRISPR-Cas Systems - genetics Drug development Editing Editors Gene Editing Gene Function Gene therapy Genetic diversity Genomes Human Genetics Medical research News & Views news-and-views Nucleotide sequence Patients Polymorphism Product design Product safety Product testing Sickle cell disease
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Beschreibung
Zusammenfassung:	CRISPR cell and gene therapy have been designed largely with respect to a single reference human genome. A new study reveals how human genetic diversity could lead to off-target effects and presents a new tool to identify these risks.
ISSN:	1061-4036 1546-1718 1546-1718
DOI:	10.1038/s41588-022-01272-z