Tibial quantitative ultrasound compared to dual-energy X-ray absorptiometry in preterm infants

Objective The gold standard for diagnosing metabolic bone disease in pediatrics is dual-energy x-ray absorptiometry (DXA). Bone quantitative ultrasound (QUS) has increasing applications. This study compared the relationship of DXA to QUS in preterm infants. Design Prospective observational study of...

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Veröffentlicht in:	Journal of perinatology 2023-05, Vol.43 (5), p.642-646
Hauptverfasser:	Tarrell, Ariel, Grinsell, Matthew, Murray, Mary, Lewis, Kimberlee Weaver, Yoder, Bradley A., Jenkins, Sabrina Malone
Format:	Artikel
Sprache:	eng
Schlagworte:	692/163/2743/316 692/699/2743/316 Absorptiometry, Photon Bone Density Bone diseases Bone mineral content Child Correlation Dual energy X-ray absorptiometry Gestation Gestational age Humans Infant, Newborn Infant, Premature Infants Medical diagnosis Medicine Medicine & Public Health Metabolic disorders Neonates Pediatric Surgery Pediatrics Premature babies Statistical analysis Ultrasonic imaging Ultrasonography Ultrasound X-rays
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Zusammenfassung:	Objective The gold standard for diagnosing metabolic bone disease in pediatrics is dual-energy x-ray absorptiometry (DXA). Bone quantitative ultrasound (QUS) has increasing applications. This study compared the relationship of DXA to QUS in preterm infants. Design Prospective observational study of preterm infants ≤32 weeks gestation or ≤1800 grams at birth. DXA scans measuring bone mineral content (BMC) and tibial QUS scans measuring bone speed of sound (SOS) were obtained near term gestation. Results 41 infants had bone scans at mean corrected gestation 37.7 ± 2.1 weeks. BMC and SOS showed weak inverse correlation (R 2 0.163, p
ISSN:	0743-8346 1476-5543
DOI:	10.1038/s41372-022-01588-y