Prognostic significance of head and neck spindle cell carcinoma
Background Our study investigates the prognostic significance of spindle cell histology on overall survival (OS) of conventional head and neck squamous cell carcinoma (HNSCC). Methods The 2004 to 2017 National Cancer Database was queried for patients with head and neck spindle cell carcinoma (HNSpCC...
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| Veröffentlicht in: | Head & neck 2023-03, Vol.45 (3), p.685-696 |
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| container_title | Head & neck |
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| creator | Patel, Aman M. Choudhry, Hannaan S. Desai, Amar D. Shah, Vraj P. Patel, Prayag Eloy, Jean Anderson Roden, Dylan F. Fang, Christina H. |
| description | Background
Our study investigates the prognostic significance of spindle cell histology on overall survival (OS) of conventional head and neck squamous cell carcinoma (HNSCC).
Methods
The 2004 to 2017 National Cancer Database was queried for patients with head and neck spindle cell carcinoma (HNSpCC) (n = 1572) or HNSCC (n = 242 697) of the oral cavity, major salivary glands, sinonasal tract, oropharynx, hypopharynx, and larynx treated with curative intent.
Results
Patients with HNSpCC presented more frequently with higher‐grade tumors and cN0 disease than those with HNSCC (p |
| doi_str_mv | 10.1002/hed.27285 |
| format | Article |
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Our study investigates the prognostic significance of spindle cell histology on overall survival (OS) of conventional head and neck squamous cell carcinoma (HNSCC).
Methods
The 2004 to 2017 National Cancer Database was queried for patients with head and neck spindle cell carcinoma (HNSpCC) (n = 1572) or HNSCC (n = 242 697) of the oral cavity, major salivary glands, sinonasal tract, oropharynx, hypopharynx, and larynx treated with curative intent.
Results
Patients with HNSpCC presented more frequently with higher‐grade tumors and cN0 disease than those with HNSCC (p < 0.001). In the oral cavity, the HR for death for SpCC compared with SCC was 1.33 (p < 0.001). In the oropharynx, the HR for death for SpCC compared with SCC was 1.47 (p = 0.028).
Conclusions
After adjusting for patient, tumor, and treatment characteristics, SpCC histology had an independent adverse prognostic effect on OS in the oral cavity and oropharynx. SpCC histology does not necessarily portend poorer survival in all HNSCC.
Level of Evidence: 4.</description><identifier>ISSN: 1043-3074</identifier><identifier>EISSN: 1097-0347</identifier><identifier>DOI: 10.1002/hed.27285</identifier><identifier>PMID: 36584171</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Cancer ; Carcinoma, Squamous Cell - pathology ; Cell survival ; Head & neck cancer ; Head and neck carcinoma ; Head and Neck Neoplasms - therapy ; Histology ; Humans ; Hypopharynx ; Larynx ; National Cancer Database ; Oral cavity ; Oropharynx ; overall survival ; primary site ; Prognosis ; Salivary gland ; spindle cell ; squamous cell ; Squamous cell carcinoma ; Squamous Cell Carcinoma of Head and Neck - therapy ; Tumors</subject><ispartof>Head & neck, 2023-03, Vol.45 (3), p.685-696</ispartof><rights>2022 Wiley Periodicals LLC.</rights><rights>2023 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3535-2ed3592dfc55d5d10d43ea5a9f590797086bf6344e2da592ac1127f026d240cf3</citedby><cites>FETCH-LOGICAL-c3535-2ed3592dfc55d5d10d43ea5a9f590797086bf6344e2da592ac1127f026d240cf3</cites><orcidid>0000-0003-0794-041X ; 0000-0003-2893-7818</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fhed.27285$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fhed.27285$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36584171$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Patel, Aman M.</creatorcontrib><creatorcontrib>Choudhry, Hannaan S.</creatorcontrib><creatorcontrib>Desai, Amar D.</creatorcontrib><creatorcontrib>Shah, Vraj P.</creatorcontrib><creatorcontrib>Patel, Prayag</creatorcontrib><creatorcontrib>Eloy, Jean Anderson</creatorcontrib><creatorcontrib>Roden, Dylan F.</creatorcontrib><creatorcontrib>Fang, Christina H.</creatorcontrib><title>Prognostic significance of head and neck spindle cell carcinoma</title><title>Head & neck</title><addtitle>Head Neck</addtitle><description>Background
Our study investigates the prognostic significance of spindle cell histology on overall survival (OS) of conventional head and neck squamous cell carcinoma (HNSCC).
Methods
The 2004 to 2017 National Cancer Database was queried for patients with head and neck spindle cell carcinoma (HNSpCC) (n = 1572) or HNSCC (n = 242 697) of the oral cavity, major salivary glands, sinonasal tract, oropharynx, hypopharynx, and larynx treated with curative intent.
Results
Patients with HNSpCC presented more frequently with higher‐grade tumors and cN0 disease than those with HNSCC (p < 0.001). In the oral cavity, the HR for death for SpCC compared with SCC was 1.33 (p < 0.001). In the oropharynx, the HR for death for SpCC compared with SCC was 1.47 (p = 0.028).
Conclusions
After adjusting for patient, tumor, and treatment characteristics, SpCC histology had an independent adverse prognostic effect on OS in the oral cavity and oropharynx. SpCC histology does not necessarily portend poorer survival in all HNSCC.
Level of Evidence: 4.</description><subject>Cancer</subject><subject>Carcinoma, Squamous Cell - pathology</subject><subject>Cell survival</subject><subject>Head & neck cancer</subject><subject>Head and neck carcinoma</subject><subject>Head and Neck Neoplasms - therapy</subject><subject>Histology</subject><subject>Humans</subject><subject>Hypopharynx</subject><subject>Larynx</subject><subject>National Cancer Database</subject><subject>Oral cavity</subject><subject>Oropharynx</subject><subject>overall survival</subject><subject>primary site</subject><subject>Prognosis</subject><subject>Salivary gland</subject><subject>spindle cell</subject><subject>squamous cell</subject><subject>Squamous cell carcinoma</subject><subject>Squamous Cell Carcinoma of Head and Neck - therapy</subject><subject>Tumors</subject><issn>1043-3074</issn><issn>1097-0347</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10MtKAzEUBuAgiq2XhS8gATe6mDbXSbMSqdUKBV3oekhzaVNnMnXSQfr2pk67EVydw-Hj5_ADcIXRACNEhktrBkSQET8CfYykyBBl4ni3M5pRJFgPnMW4QgjRnJFT0KM5HzEscB_cvzX1ItRx4zWMfhG881oFbWHt4NIqA1UwMFj9CePaB1NaqG1ZQq0a7UNdqQtw4lQZ7eV-noOPp8n7eJrNXp9fxg-zTFNOeUasoVwS4zTnhhuMDKNWcSUdl0hIgUb53OWUMUuMSlBpjIlwiOSGMKQdPQe3Xe66qb9aGzdF5ePuFRVs3caCCC5ljtJI9OYPXdVtE9J3SQnMpBxhltRdp3RTx9hYV6wbX6lmW2BU7FotUqvFb6vJXu8T23mVrgd5qDGBYQe-fWm3_ycV08ljF_kDnd9-sw</recordid><startdate>202303</startdate><enddate>202303</enddate><creator>Patel, Aman M.</creator><creator>Choudhry, Hannaan S.</creator><creator>Desai, Amar D.</creator><creator>Shah, Vraj P.</creator><creator>Patel, Prayag</creator><creator>Eloy, Jean Anderson</creator><creator>Roden, Dylan F.</creator><creator>Fang, Christina H.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-0794-041X</orcidid><orcidid>https://orcid.org/0000-0003-2893-7818</orcidid></search><sort><creationdate>202303</creationdate><title>Prognostic significance of head and neck spindle cell carcinoma</title><author>Patel, Aman M. ; Choudhry, Hannaan S. ; Desai, Amar D. ; Shah, Vraj P. ; Patel, Prayag ; Eloy, Jean Anderson ; Roden, Dylan F. ; Fang, Christina H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3535-2ed3592dfc55d5d10d43ea5a9f590797086bf6344e2da592ac1127f026d240cf3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Cancer</topic><topic>Carcinoma, Squamous Cell - pathology</topic><topic>Cell survival</topic><topic>Head & neck cancer</topic><topic>Head and neck carcinoma</topic><topic>Head and Neck Neoplasms - therapy</topic><topic>Histology</topic><topic>Humans</topic><topic>Hypopharynx</topic><topic>Larynx</topic><topic>National Cancer Database</topic><topic>Oral cavity</topic><topic>Oropharynx</topic><topic>overall survival</topic><topic>primary site</topic><topic>Prognosis</topic><topic>Salivary gland</topic><topic>spindle cell</topic><topic>squamous cell</topic><topic>Squamous cell carcinoma</topic><topic>Squamous Cell Carcinoma of Head and Neck - therapy</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Patel, Aman M.</creatorcontrib><creatorcontrib>Choudhry, Hannaan S.</creatorcontrib><creatorcontrib>Desai, Amar D.</creatorcontrib><creatorcontrib>Shah, Vraj P.</creatorcontrib><creatorcontrib>Patel, Prayag</creatorcontrib><creatorcontrib>Eloy, Jean Anderson</creatorcontrib><creatorcontrib>Roden, Dylan F.</creatorcontrib><creatorcontrib>Fang, Christina H.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Head & neck</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Patel, Aman M.</au><au>Choudhry, Hannaan S.</au><au>Desai, Amar D.</au><au>Shah, Vraj P.</au><au>Patel, Prayag</au><au>Eloy, Jean Anderson</au><au>Roden, Dylan F.</au><au>Fang, Christina H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prognostic significance of head and neck spindle cell carcinoma</atitle><jtitle>Head & neck</jtitle><addtitle>Head Neck</addtitle><date>2023-03</date><risdate>2023</risdate><volume>45</volume><issue>3</issue><spage>685</spage><epage>696</epage><pages>685-696</pages><issn>1043-3074</issn><eissn>1097-0347</eissn><abstract>Background
Our study investigates the prognostic significance of spindle cell histology on overall survival (OS) of conventional head and neck squamous cell carcinoma (HNSCC).
Methods
The 2004 to 2017 National Cancer Database was queried for patients with head and neck spindle cell carcinoma (HNSpCC) (n = 1572) or HNSCC (n = 242 697) of the oral cavity, major salivary glands, sinonasal tract, oropharynx, hypopharynx, and larynx treated with curative intent.
Results
Patients with HNSpCC presented more frequently with higher‐grade tumors and cN0 disease than those with HNSCC (p < 0.001). In the oral cavity, the HR for death for SpCC compared with SCC was 1.33 (p < 0.001). In the oropharynx, the HR for death for SpCC compared with SCC was 1.47 (p = 0.028).
Conclusions
After adjusting for patient, tumor, and treatment characteristics, SpCC histology had an independent adverse prognostic effect on OS in the oral cavity and oropharynx. SpCC histology does not necessarily portend poorer survival in all HNSCC.
Level of Evidence: 4.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>36584171</pmid><doi>10.1002/hed.27285</doi><tpages>12</tpages><orcidid>https://orcid.org/0000-0003-0794-041X</orcidid><orcidid>https://orcid.org/0000-0003-2893-7818</orcidid></addata></record> |
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| subjects | Cancer Carcinoma, Squamous Cell - pathology Cell survival Head & neck cancer Head and neck carcinoma Head and Neck Neoplasms - therapy Histology Humans Hypopharynx Larynx National Cancer Database Oral cavity Oropharynx overall survival primary site Prognosis Salivary gland spindle cell squamous cell Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck - therapy Tumors |
| title | Prognostic significance of head and neck spindle cell carcinoma |
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