Transition‐Metal‐Free Synthesis of Polyfluoro‐Polyarylmethanes via Direct Cross‐Coupling of Polyfluoroarenes and Benzyl Chlorides

The transition‐metal‐free direct cross‐coupling between polyfluoroarenes and benzyl chlorides is reported. In this strategy, a variety of polyfluoro di‐, tri‐ and tetra‐arylmethanes was efficiently prepared with good to excellent yields in the presence of Mg turnings via a one‐pot procedure. Significantly, this method provides a general approach for the synthesis of polyfluorinated polyarylmethanes. A general C(sp2)−C(sp3) cross‐coupling reaction of polyfluoroarenes with Grignard reagent was developed. A variety of polyfluoro di‐, tri‐, and even tetr‐arylmethanes was efficiently prepared with good to excellent yields in the presence of Mg turnings via a one‐pot procedure.