In vitro blood brain barrier models: Molecular aspects and therapeutic strategies in glioma management

Glioma management is the most challenging task in clinical oncology due to numerous reasons. One of the major hurdles in glioma therapy is the presence of blood brain barrier which resists the entry of most of the drugs into the brain. However, in case of tumors, blood brain barrier integrity is compromised, which in turn can be advantageous in delivering the drugs, if the therapeutic module is strategically modified. For such improvised therapeutic strategy, it is necessary to understand the molecular composition and profiling of blood brain barrier and blood brain tumor barrier. This review mainly focuses on the composition, markers expressed on the blood brain barrier which will help the readers to understand its basic environment. It also gives a detailed account of the various in vitro models that are used to study the nature of the blood brain barrier and describes various strategies in improvising the drug delivery in glioma management. [Display omitted] •Review highlights the in vitro blood brain barrier models in glioma therapy.•Molecular profiling of blood brain tumor barrier is explained.•Overview of heterogeneity of blood brain tumor barrier across patients is focused.•Improvising drug delivery across blood brain barrier is explained.