Effectiveness of brodalumab in improving itching and skin pain in Japanese patients with psoriasis: The ProLOGUE study

Itching and skin pain are bothersome symptoms of psoriasis, but evidence is limited regarding the treatment effectiveness on these symptoms in daily clinical settings. We assessed the changes in the levels of itching and skin pain after brodalumab treatment in Japanese patients with psoriasis using...

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Veröffentlicht in:Journal of dermatology 2023-04, Vol.50 (4), p.453-461
Hauptverfasser: Honma, Masaru, Kanai, Yasumasa, Murotani, Kenta, Ito, Kei, Ohata, Chika, Yamazaki, Fumikazu, Saeki, Hidehisa, Seishima, Mariko, Mizutani, Yoko, Kitabayashi, Hiroki, Imafuku, Shinichi
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Sprache:eng
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Zusammenfassung:Itching and skin pain are bothersome symptoms of psoriasis, but evidence is limited regarding the treatment effectiveness on these symptoms in daily clinical settings. We assessed the changes in the levels of itching and skin pain after brodalumab treatment in Japanese patients with psoriasis using patient‐reported outcomes (PROs). Patients with psoriasis who have inadequate response to existing treatments were enrolled in the single‐arm, open‐label, multicenter, prospective ProLOGUE study and received brodalumab 210 mg subcutaneously in daily clinical practice. Psoriasis Area and Severity Index (PASI) and PRO assessments were performed at baseline and weeks 12 and 48. Seventy‐three patients (men, 82.2%; median age, 54.0 years) were enrolled. The Itch Numeric Rating Scale (NRS; p 
ISSN:0385-2407
1346-8138
DOI:10.1111/1346-8138.16682