Electrochemical Selenium-Catalyzed N,O-Difunctionalization of Ynamides: Access to Polysubstituted Oxazoles

A green and efficient approach for the difunctionalization of ynamides by merging the electrochemical and organoselenium-catalyzed processes is described. This strategy features mild reaction conditions, broad functional group tolerance and high atom-economy, and requires no external chemical oxidant. Hence, we provide a sustainable alternative for the synthesis of polysubstituted oxazoles.