Molecular weight-dependent hyaluronic acid permeability and tight junction modulation in human buccal TR146 cell monolayers

The oral route is considered an attractive method for drug delivery, as it avoids the hepatic and intestinal first-pass metabolism processes. Hyaluronic acid (HA) beneficial effects to the human body include anti-aging and wound healing but its effects on oral barrier integrity and mechanical functi...

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Veröffentlicht in:	International journal of biological macromolecules 2023-02, Vol.227, p.182-192
Hauptverfasser:	Park, Ha-Young, Kweon, Dong-Keon, Kim, Jae-Kyung
Format:	Artikel
Sprache:	eng
Schlagworte:	Caco-2 Cells Humans Hyaluronic acid Hyaluronic Acid - metabolism Hyaluronic Acid - pharmacology Intestinal Mucosa - metabolism Molecular Weight Oral permeation Permeability Tight junction Tight Junctions TR146 cell monolayers
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Zusammenfassung:	The oral route is considered an attractive method for drug delivery, as it avoids the hepatic and intestinal first-pass metabolism processes. Hyaluronic acid (HA) beneficial effects to the human body include anti-aging and wound healing but its effects on oral barrier integrity and mechanical function have not yet been investigated. In this study, we analyzed oral barrier integrity and the paracellular pathway of HA transportation in TR146 cell monolayers during and after permeation and using low molecular weight HA (LMW-HA, 500 kDa). Cytotoxicity assays in TR146 cells revealed that neither LMW-HA or HMW-HA altered cell viability at concentrations
ISSN:	0141-8130 1879-0003
DOI:	10.1016/j.ijbiomac.2022.12.106