Nonlinear N – Compartments model of respiratory mechanics considering viscoelasticity, inertia and surface tension properties

Respiratory biomechanics constitutes an important topic in clinical practice. Different strategies like mathematical models have been implemented to understand and replicate scenarios allowing deeper analysis. In this paper, a nonlinear N - compartments model is presented, allowing to represent the lung in a heterogeneous way. It considers the resistance of each generation of the airway and each alveolar compartment characterized independently. Includes properties of nonlinear elastance, viscoelasticity, inertia, and surface tension. In this work, to show the functionality of the model, a simulation of four alveolar units coupled to the airway model is presented using pressure as input signal simulating mechanical ventilation. However, the model can be used to simulate any desired number of alveolar units. Values at airway output were compared to the linear model, obtaining a correlation close to 1. Also, was compared to a physical test lung using Hamilton - S1 mechanical ventilator obtaining a positive correlation. The model makes it possible to evaluate the effects of different properties during spontaneous respiration or mechanical ventilation, both at the airway opening and alveolar. These properties include viscoelasticity, surface tension, inertia, among others. •The model includes viscoelasticity, inertial forces and surface tension.•The results are obtained for each N alveolar units and airway generation.•Regional parameters allow simulates certain diseases including lung heterogeneity.•Measured variables showed a proper correlation index allowing to validate the model.•The model was compared regarding to linear model and physical experiments.