Engineering yeast for industrial-level production of the antimalarial drug artemisinin

Artemisinin-based combination therapies are the gold standard treatment for uncomplicated malaria. A seminal study by Paddon et al. detailed an efficient approach for producing artemisinic acid from engineered yeast and its conversion to artemisinin, and demonstrated how to use metabolic engineering...

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Veröffentlicht in:	Trends in biotechnology (Regular ed.) 2023-03, Vol.41 (3), p.267-269
Hauptverfasser:	Smith, Ayoola B., Chekan, Jonathan R.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Alcohol Antimalarials - metabolism Antimalarials - therapeutic use Antiparasitic agents Artemisinin Artemisinins - metabolism Artemisinins - therapeutic use Bioactive compounds Dehydrogenases Malaria Metabolic engineering Natural products Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - metabolism Synthetic biology Vector-borne diseases Yeast Yeasts
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Beschreibung
Zusammenfassung:	Artemisinin-based combination therapies are the gold standard treatment for uncomplicated malaria. A seminal study by Paddon et al. detailed an efficient approach for producing artemisinic acid from engineered yeast and its conversion to artemisinin, and demonstrated how to use metabolic engineering and synthetic biology for the production of bioactive compounds.
ISSN:	0167-7799 1879-3096
DOI:	10.1016/j.tibtech.2022.12.007