RNA Sequencing as a Diagnostic Tool

RNA Sequencing as a Diagnostic Tool

This JAMA Insights discusses RNA sequencing, which allows detection of qualitative and quantitative changes in RNA expression across the genome in clinical samples, and how it may improve molecular diagnostic rates achieved by diagnostic exome sequencing and whole-genome sequencing alone.

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Veröffentlicht in:JAMA : the journal of the American Medical Association 2023-01, Vol.329 (1), p.85-86
Hauptverfasser: Ketkar, Shamika, Burrage, Lindsay C, Lee, Brendan
Format: Artikel
Sprache:eng
Schlagworte:
Base Sequence
DNA microarrays
Exome
Gene expression
Gene sequencing
Genomes
High-Throughput Nucleotide Sequencing
Medical diagnosis
Next-generation sequencing
Ribonucleic acid
RNA
Sequence Analysis, RNA
Technology
Whole genome sequencing
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Beschreibung
Zusammenfassung:This JAMA Insights discusses RNA sequencing, which allows detection of qualitative and quantitative changes in RNA expression across the genome in clinical samples, and how it may improve molecular diagnostic rates achieved by diagnostic exome sequencing and whole-genome sequencing alone.
ISSN:0098-7484
1538-3598
DOI:10.1001/jama.2022.22843