Lack of difference between amyloid‐beta burden at gyral crests and sulcal depths in diverse neurodegenerative diseases

Aims The aim of this study is to clarify whether there is a difference in amyloid‐beta burden between gyral crests (GCs) and sulcal depths (SDs) in different neurodegenerative proteinopathies. Methods We analysed the burden and distribution of amyloid‐beta deposition in post‐mortem brain samples from 138 autopsies, including Alzheimer's disease (n = 30), Down's syndrome (n = 11), Lewy body disease (LBD; n = 53), multiple system atrophy (n = 8) and progressive supranuclear palsy (n = 36). We applied quantitative amyloid‐beta burden analysis to compare amyloid‐beta deposition in both GCs and SDs. We also evaluated the prevalence of amyloid‐beta plaques in both regions in samples exhibiting high or low amounts of amyloid‐beta pathology. Results Amyloid‐beta burden was evaluated in 67 and 84 samples of the frontal and temporal cortices, respectively. We did not find significant differences in the amyloid‐beta burden between GCs and SDs in these regions in any examined disease. In addition, amyloid‐beta plaques were almost evenly distributed in both regions in cases with low amounts of amyloid‐beta pathology. Females in the LBD group showed significantly higher amyloid‐beta burden than males (temporal cortex, p