Borderline indications for ovarian suppression: addressing uncertainties with patients

Ovarian function suppression (OFS) is a potentially life-saving treatment for young women diagnosed with high-risk hormonal-receptor (HR)+ early breast cancer (EBC), albeit one associated with significant side effects that may adversely affect quality of life. Of particular concern, this article raises a few borderline indications that were largely unaddressed in pivotal clinical trials but are still commonly encountered in daily practice. These, referred to here as ‘borderline indications of OFS' remain a source of uncertainty for patients and physicians and are concisely addressed in this article. This article is about a treatment for breast cancer that is a type of drug-induced menopause. It is considered highly effective for young women diagnosed with a specific form of breast cancer. However, it often causes significant side effects. The author addresses several situations, commonly encountered in daily medical practice, in which the indication for this treatment is controversial.