Lipid accumulation product is closely associated with hypertension and prehypertension in prediabetic population in China: results from the REACTION study
Prediabetes with hypertension or prehypertension increases the risk of cardiovascular events. Lipid accumulation product (LAP) is a powerful marker of visceral obesity. The current study aimed to explore the relationship between LAP and hypertension and prehypertension among prediabetic individuals....
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| Veröffentlicht in: | Hypertension research 2023-03, Vol.46 (3), p.708-719 |
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| creator | Li, Binqi Wang, Jie Zhou, Xin Wang, Weiqing Gao, Zhengnan Tang, Xulei Yan, Li Wan, Qin Luo, Zuojie Qin, Guijun Chen, Lulu Ning, Guang Mu, Yiming |
| description | Prediabetes with hypertension or prehypertension increases the risk of cardiovascular events. Lipid accumulation product (LAP) is a powerful marker of visceral obesity. The current study aimed to explore the relationship between LAP and hypertension and prehypertension among prediabetic individuals. A total of 12,388 prediabetic participants from the REACTION study were recruited. LAP was calculated from waist circumference and fasting triglyceride levels. Multiple logistic regression models were conducted to assess the relationship between LAP and hypertension and prehypertension. Multiple logistic regression analysis showed that elevated LAP was associated with hypertension (Q2: odds ratio (OR): 1.263, P |
| doi_str_mv | 10.1038/s41440-022-01113-w |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2754503092</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2754503092</sourcerecordid><originalsourceid>FETCH-LOGICAL-c355t-a40f9e7731f3e34f96ff2b855c3f0ebfa306d4056c2487d5afd52b7ed8a4d8fd3</originalsourceid><addsrcrecordid>eNpdkc2KFDEURoMoTjv6Ai4k4MZNaX6rUu6GZtSBxgEZ1yGV3NAZqiplkqLpV_FpJ23PCLoK3Jzv414OQm8p-UgJV5-yoEKQhjDWEEopbw7P0IZyoRrBqHiONqSnbdO3vL1Ar3K-J4Qp2dOX6IK3kvJOiA36vQtLcNhYu07raEqIM15SdKstOGRsx5hhPGKTc7TBFHD4EMoe748LpAJzPvFmdjUD_8zCqQZcMAOUYPESl6f2-rPdh9l8xgnyOpaMfYoTLnvAP66vtnc3t99xLqs7vkYvvBkzvHl8L9HPL9d322_N7vbrzfZq11guZWmMIL6HruPUc-DC9633bFBSWu4JDN5w0jpBZGuZUJ2TxjvJhg6cMsIp7_gl-nDurXf_WiEXPYVsYRzNDHHNmnVSSMJJzyr6_j_0Pq5prttVSjEleE_aSrEzZVPMOYHXSwqTSUdNiT6Z02dzuprTf8zpQw29e6xehwnc38iTKv4AxzSX2A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2782843906</pqid></control><display><type>article</type><title>Lipid accumulation product is closely associated with hypertension and prehypertension in prediabetic population in China: results from the REACTION study</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Li, Binqi ; Wang, Jie ; Zhou, Xin ; Wang, Weiqing ; Gao, Zhengnan ; Tang, Xulei ; Yan, Li ; Wan, Qin ; Luo, Zuojie ; Qin, Guijun ; Chen, Lulu ; Ning, Guang ; Mu, Yiming</creator><creatorcontrib>Li, Binqi ; Wang, Jie ; Zhou, Xin ; Wang, Weiqing ; Gao, Zhengnan ; Tang, Xulei ; Yan, Li ; Wan, Qin ; Luo, Zuojie ; Qin, Guijun ; Chen, Lulu ; Ning, Guang ; Mu, Yiming</creatorcontrib><description>Prediabetes with hypertension or prehypertension increases the risk of cardiovascular events. Lipid accumulation product (LAP) is a powerful marker of visceral obesity. The current study aimed to explore the relationship between LAP and hypertension and prehypertension among prediabetic individuals. A total of 12,388 prediabetic participants from the REACTION study were recruited. LAP was calculated from waist circumference and fasting triglyceride levels. Multiple logistic regression models were conducted to assess the relationship between LAP and hypertension and prehypertension. Multiple logistic regression analysis showed that elevated LAP was associated with hypertension (Q2: odds ratio (OR): 1.263, P < 0.001; Q3: OR: 1.613, P < 0.001; Q4: OR: 1.754, P < 0.001) and prehypertension (Q2: OR: 1.255, P = 0.005; Q3: OR: 1.340, P = 0.002; Q4: OR: 1.765, P < 0.001). The results of the stratified analysis showed that prediabetic people with higher LAP levels and characterized by overweight, normal weight and a high waist-to-hip ratio (WHR) were more likely to have hypertension, and prediabetic people with higher LAP levels and characterized by overweight, normal weight, a high WHR, age <65, and low and high levels of physical activity were more likely to have prehypertension. In conclusion, visceral obesity assessed by LAP is significantly associated with hypertension and prehypertension in the Chinese prediabetic population.</description><identifier>ISSN: 0916-9636</identifier><identifier>EISSN: 1348-4214</identifier><identifier>DOI: 10.1038/s41440-022-01113-w</identifier><identifier>PMID: 36513744</identifier><language>eng</language><publisher>England: Nature Publishing Group</publisher><subject>Body fat ; Body Mass Index ; China - epidemiology ; Cholesterol ; Diabetes ; Endocrinology ; Glucose ; Humans ; Hypertension ; Lipid Accumulation Product ; Lipids ; Metabolic disorders ; Obesity ; Obesity, Abdominal - complications ; Overweight ; Overweight - complications ; Prediabetic State ; Prehypertension ; Questionnaires ; Regression analysis ; Risk Factors</subject><ispartof>Hypertension research, 2023-03, Vol.46 (3), p.708-719</ispartof><rights>2022. The Author(s), under exclusive licence to The Japanese Society of Hypertension.</rights><rights>The Author(s), under exclusive licence to The Japanese Society of Hypertension 2022. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c355t-a40f9e7731f3e34f96ff2b855c3f0ebfa306d4056c2487d5afd52b7ed8a4d8fd3</citedby><cites>FETCH-LOGICAL-c355t-a40f9e7731f3e34f96ff2b855c3f0ebfa306d4056c2487d5afd52b7ed8a4d8fd3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36513744$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Li, Binqi</creatorcontrib><creatorcontrib>Wang, Jie</creatorcontrib><creatorcontrib>Zhou, Xin</creatorcontrib><creatorcontrib>Wang, Weiqing</creatorcontrib><creatorcontrib>Gao, Zhengnan</creatorcontrib><creatorcontrib>Tang, Xulei</creatorcontrib><creatorcontrib>Yan, Li</creatorcontrib><creatorcontrib>Wan, Qin</creatorcontrib><creatorcontrib>Luo, Zuojie</creatorcontrib><creatorcontrib>Qin, Guijun</creatorcontrib><creatorcontrib>Chen, Lulu</creatorcontrib><creatorcontrib>Ning, Guang</creatorcontrib><creatorcontrib>Mu, Yiming</creatorcontrib><title>Lipid accumulation product is closely associated with hypertension and prehypertension in prediabetic population in China: results from the REACTION study</title><title>Hypertension research</title><addtitle>Hypertens Res</addtitle><description>Prediabetes with hypertension or prehypertension increases the risk of cardiovascular events. Lipid accumulation product (LAP) is a powerful marker of visceral obesity. The current study aimed to explore the relationship between LAP and hypertension and prehypertension among prediabetic individuals. A total of 12,388 prediabetic participants from the REACTION study were recruited. LAP was calculated from waist circumference and fasting triglyceride levels. Multiple logistic regression models were conducted to assess the relationship between LAP and hypertension and prehypertension. Multiple logistic regression analysis showed that elevated LAP was associated with hypertension (Q2: odds ratio (OR): 1.263, P < 0.001; Q3: OR: 1.613, P < 0.001; Q4: OR: 1.754, P < 0.001) and prehypertension (Q2: OR: 1.255, P = 0.005; Q3: OR: 1.340, P = 0.002; Q4: OR: 1.765, P < 0.001). The results of the stratified analysis showed that prediabetic people with higher LAP levels and characterized by overweight, normal weight and a high waist-to-hip ratio (WHR) were more likely to have hypertension, and prediabetic people with higher LAP levels and characterized by overweight, normal weight, a high WHR, age <65, and low and high levels of physical activity were more likely to have prehypertension. In conclusion, visceral obesity assessed by LAP is significantly associated with hypertension and prehypertension in the Chinese prediabetic population.</description><subject>Body fat</subject><subject>Body Mass Index</subject><subject>China - epidemiology</subject><subject>Cholesterol</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Glucose</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Lipid Accumulation Product</subject><subject>Lipids</subject><subject>Metabolic disorders</subject><subject>Obesity</subject><subject>Obesity, Abdominal - complications</subject><subject>Overweight</subject><subject>Overweight - complications</subject><subject>Prediabetic State</subject><subject>Prehypertension</subject><subject>Questionnaires</subject><subject>Regression analysis</subject><subject>Risk Factors</subject><issn>0916-9636</issn><issn>1348-4214</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNpdkc2KFDEURoMoTjv6Ai4k4MZNaX6rUu6GZtSBxgEZ1yGV3NAZqiplkqLpV_FpJ23PCLoK3Jzv414OQm8p-UgJV5-yoEKQhjDWEEopbw7P0IZyoRrBqHiONqSnbdO3vL1Ar3K-J4Qp2dOX6IK3kvJOiA36vQtLcNhYu07raEqIM15SdKstOGRsx5hhPGKTc7TBFHD4EMoe748LpAJzPvFmdjUD_8zCqQZcMAOUYPESl6f2-rPdh9l8xgnyOpaMfYoTLnvAP66vtnc3t99xLqs7vkYvvBkzvHl8L9HPL9d322_N7vbrzfZq11guZWmMIL6HruPUc-DC9633bFBSWu4JDN5w0jpBZGuZUJ2TxjvJhg6cMsIp7_gl-nDurXf_WiEXPYVsYRzNDHHNmnVSSMJJzyr6_j_0Pq5prttVSjEleE_aSrEzZVPMOYHXSwqTSUdNiT6Z02dzuprTf8zpQw29e6xehwnc38iTKv4AxzSX2A</recordid><startdate>20230301</startdate><enddate>20230301</enddate><creator>Li, Binqi</creator><creator>Wang, Jie</creator><creator>Zhou, Xin</creator><creator>Wang, Weiqing</creator><creator>Gao, Zhengnan</creator><creator>Tang, Xulei</creator><creator>Yan, Li</creator><creator>Wan, Qin</creator><creator>Luo, Zuojie</creator><creator>Qin, Guijun</creator><creator>Chen, Lulu</creator><creator>Ning, Guang</creator><creator>Mu, Yiming</creator><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20230301</creationdate><title>Lipid accumulation product is closely associated with hypertension and prehypertension in prediabetic population in China: results from the REACTION study</title><author>Li, Binqi ; Wang, Jie ; Zhou, Xin ; Wang, Weiqing ; Gao, Zhengnan ; Tang, Xulei ; Yan, Li ; Wan, Qin ; Luo, Zuojie ; Qin, Guijun ; Chen, Lulu ; Ning, Guang ; Mu, Yiming</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c355t-a40f9e7731f3e34f96ff2b855c3f0ebfa306d4056c2487d5afd52b7ed8a4d8fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Body fat</topic><topic>Body Mass Index</topic><topic>China - epidemiology</topic><topic>Cholesterol</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Glucose</topic><topic>Humans</topic><topic>Hypertension</topic><topic>Lipid Accumulation Product</topic><topic>Lipids</topic><topic>Metabolic disorders</topic><topic>Obesity</topic><topic>Obesity, Abdominal - complications</topic><topic>Overweight</topic><topic>Overweight - complications</topic><topic>Prediabetic State</topic><topic>Prehypertension</topic><topic>Questionnaires</topic><topic>Regression analysis</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Li, Binqi</creatorcontrib><creatorcontrib>Wang, Jie</creatorcontrib><creatorcontrib>Zhou, Xin</creatorcontrib><creatorcontrib>Wang, Weiqing</creatorcontrib><creatorcontrib>Gao, Zhengnan</creatorcontrib><creatorcontrib>Tang, Xulei</creatorcontrib><creatorcontrib>Yan, Li</creatorcontrib><creatorcontrib>Wan, Qin</creatorcontrib><creatorcontrib>Luo, Zuojie</creatorcontrib><creatorcontrib>Qin, Guijun</creatorcontrib><creatorcontrib>Chen, Lulu</creatorcontrib><creatorcontrib>Ning, Guang</creatorcontrib><creatorcontrib>Mu, Yiming</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Hypertension research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Li, Binqi</au><au>Wang, Jie</au><au>Zhou, Xin</au><au>Wang, Weiqing</au><au>Gao, Zhengnan</au><au>Tang, Xulei</au><au>Yan, Li</au><au>Wan, Qin</au><au>Luo, Zuojie</au><au>Qin, Guijun</au><au>Chen, Lulu</au><au>Ning, Guang</au><au>Mu, Yiming</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipid accumulation product is closely associated with hypertension and prehypertension in prediabetic population in China: results from the REACTION study</atitle><jtitle>Hypertension research</jtitle><addtitle>Hypertens Res</addtitle><date>2023-03-01</date><risdate>2023</risdate><volume>46</volume><issue>3</issue><spage>708</spage><epage>719</epage><pages>708-719</pages><issn>0916-9636</issn><eissn>1348-4214</eissn><abstract>Prediabetes with hypertension or prehypertension increases the risk of cardiovascular events. Lipid accumulation product (LAP) is a powerful marker of visceral obesity. The current study aimed to explore the relationship between LAP and hypertension and prehypertension among prediabetic individuals. A total of 12,388 prediabetic participants from the REACTION study were recruited. LAP was calculated from waist circumference and fasting triglyceride levels. Multiple logistic regression models were conducted to assess the relationship between LAP and hypertension and prehypertension. Multiple logistic regression analysis showed that elevated LAP was associated with hypertension (Q2: odds ratio (OR): 1.263, P < 0.001; Q3: OR: 1.613, P < 0.001; Q4: OR: 1.754, P < 0.001) and prehypertension (Q2: OR: 1.255, P = 0.005; Q3: OR: 1.340, P = 0.002; Q4: OR: 1.765, P < 0.001). The results of the stratified analysis showed that prediabetic people with higher LAP levels and characterized by overweight, normal weight and a high waist-to-hip ratio (WHR) were more likely to have hypertension, and prediabetic people with higher LAP levels and characterized by overweight, normal weight, a high WHR, age <65, and low and high levels of physical activity were more likely to have prehypertension. In conclusion, visceral obesity assessed by LAP is significantly associated with hypertension and prehypertension in the Chinese prediabetic population.</abstract><cop>England</cop><pub>Nature Publishing Group</pub><pmid>36513744</pmid><doi>10.1038/s41440-022-01113-w</doi><tpages>12</tpages></addata></record> |
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| subjects | Body fat Body Mass Index China - epidemiology Cholesterol Diabetes Endocrinology Glucose Humans Hypertension Lipid Accumulation Product Lipids Metabolic disorders Obesity Obesity, Abdominal - complications Overweight Overweight - complications Prediabetic State Prehypertension Questionnaires Regression analysis Risk Factors |
| title | Lipid accumulation product is closely associated with hypertension and prehypertension in prediabetic population in China: results from the REACTION study |
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