Computational analysis of retinal image quality with different contact lens designs in keratoconus
To determine 1) the relative differences in optical quality of keratoconic eyes fitted with four routinely used CL designs and 2) the Zernike coefficients in the residual wavefront aberration map that may be responsible for differences in the optical quality of keratoconic eyes fitted with these CLs...
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| Veröffentlicht in: | Contact lens & anterior eye 2023-04, Vol.46 (2), p.101794-101794, Article 101794 |
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| container_title | Contact lens & anterior eye |
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| creator | Devi, Preetirupa Kumar, Preetam Bharadwaj, Shrikant R. |
| description | To determine 1) the relative differences in optical quality of keratoconic eyes fitted with four routinely used CL designs and 2) the Zernike coefficients in the residual wavefront aberration map that may be responsible for differences in the optical quality of keratoconic eyes fitted with these CLs.
Wavefront aberrations over a 3-mm pupil diameter were measured without and with Kerasoft IC®, Rose K2®, conventional spherical Rigid Gas Permeable (RGP), and Scleral CLs in 15 mild to moderate keratoconic eyes (20 – 28 years) and under unaided viewing in 10 age-similar non-contact lens wearing controls. The resultant through-focus curves constructed for the logarithm of Neural Sharpness (logNS) Image Quality (IQ) metric were quantified in terms of peak value, best focus, and depth of focus. Sensitivity analyses determined the impact of the residual Zernike coefficients of keratoconic eyes fitted with CLs on the IQ of controls at emmetropic refraction.
The peak IQ and depth of focus were similar with Rose K2®, conventional RGP, and Scleral CLs (p > 0.05, for all) but significantly better than Kerasoft IC® CLs (p 0.2 for all). However, the IQ parameters of all the lenses remained significantly poorer than the controls (p |
| doi_str_mv | 10.1016/j.clae.2022.101794 |
| format | Article |
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Wavefront aberrations over a 3-mm pupil diameter were measured without and with Kerasoft IC®, Rose K2®, conventional spherical Rigid Gas Permeable (RGP), and Scleral CLs in 15 mild to moderate keratoconic eyes (20 – 28 years) and under unaided viewing in 10 age-similar non-contact lens wearing controls. The resultant through-focus curves constructed for the logarithm of Neural Sharpness (logNS) Image Quality (IQ) metric were quantified in terms of peak value, best focus, and depth of focus. Sensitivity analyses determined the impact of the residual Zernike coefficients of keratoconic eyes fitted with CLs on the IQ of controls at emmetropic refraction.
The peak IQ and depth of focus were similar with Rose K2®, conventional RGP, and Scleral CLs (p > 0.05, for all) but significantly better than Kerasoft IC® CLs (p < 0.01 for all). Best focus was similar across all four CLs (p > 0.2 for all). However, the IQ parameters of all the lenses remained significantly poorer than the controls (p < 0.01, for all). The IQ of the controls dropped to keratoconic levels with induced residual lower-order Zernike terms and 3rd-order coma across all lenses in the sensitivity analysis (p < 0.001).
IQ of keratoconic eyes remain suboptimal with routinely dispensed CL designs, largely due to residual lower-order aberrations and coma, all relative to the controls. The performance drop appears greater for the Kerasoft IC® CL relative to the other CL designs. These results may provide the optical basis for psychophysical spatial visual performance reported earlier across these four CL designs for keratoconus.</description><identifier>ISSN: 1367-0484</identifier><identifier>EISSN: 1476-5411</identifier><identifier>DOI: 10.1016/j.clae.2022.101794</identifier><identifier>PMID: 36513565</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Coma ; Contact lens ; Contact Lenses ; Humans ; Image quality ; Keratoconus ; Keratoconus - therapy ; Lens, Crystalline ; Refraction, Ocular ; Sensitivity analysis ; Visual functions ; Wavefront aberrations</subject><ispartof>Contact lens & anterior eye, 2023-04, Vol.46 (2), p.101794-101794, Article 101794</ispartof><rights>2022 British Contact Lens Association</rights><rights>Copyright © 2022 British Contact Lens Association. Published by Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c356t-e53d41c48c6308e51002072f6072d416d65e94a456bf8d00ab5f0be77b7b8cab3</citedby><cites>FETCH-LOGICAL-c356t-e53d41c48c6308e51002072f6072d416d65e94a456bf8d00ab5f0be77b7b8cab3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1367048422002703$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/36513565$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Devi, Preetirupa</creatorcontrib><creatorcontrib>Kumar, Preetam</creatorcontrib><creatorcontrib>Bharadwaj, Shrikant R.</creatorcontrib><title>Computational analysis of retinal image quality with different contact lens designs in keratoconus</title><title>Contact lens & anterior eye</title><addtitle>Cont Lens Anterior Eye</addtitle><description>To determine 1) the relative differences in optical quality of keratoconic eyes fitted with four routinely used CL designs and 2) the Zernike coefficients in the residual wavefront aberration map that may be responsible for differences in the optical quality of keratoconic eyes fitted with these CLs.
Wavefront aberrations over a 3-mm pupil diameter were measured without and with Kerasoft IC®, Rose K2®, conventional spherical Rigid Gas Permeable (RGP), and Scleral CLs in 15 mild to moderate keratoconic eyes (20 – 28 years) and under unaided viewing in 10 age-similar non-contact lens wearing controls. The resultant through-focus curves constructed for the logarithm of Neural Sharpness (logNS) Image Quality (IQ) metric were quantified in terms of peak value, best focus, and depth of focus. Sensitivity analyses determined the impact of the residual Zernike coefficients of keratoconic eyes fitted with CLs on the IQ of controls at emmetropic refraction.
The peak IQ and depth of focus were similar with Rose K2®, conventional RGP, and Scleral CLs (p > 0.05, for all) but significantly better than Kerasoft IC® CLs (p < 0.01 for all). Best focus was similar across all four CLs (p > 0.2 for all). However, the IQ parameters of all the lenses remained significantly poorer than the controls (p < 0.01, for all). The IQ of the controls dropped to keratoconic levels with induced residual lower-order Zernike terms and 3rd-order coma across all lenses in the sensitivity analysis (p < 0.001).
IQ of keratoconic eyes remain suboptimal with routinely dispensed CL designs, largely due to residual lower-order aberrations and coma, all relative to the controls. The performance drop appears greater for the Kerasoft IC® CL relative to the other CL designs. These results may provide the optical basis for psychophysical spatial visual performance reported earlier across these four CL designs for keratoconus.</description><subject>Coma</subject><subject>Contact lens</subject><subject>Contact Lenses</subject><subject>Humans</subject><subject>Image quality</subject><subject>Keratoconus</subject><subject>Keratoconus - therapy</subject><subject>Lens, Crystalline</subject><subject>Refraction, Ocular</subject><subject>Sensitivity analysis</subject><subject>Visual functions</subject><subject>Wavefront aberrations</subject><issn>1367-0484</issn><issn>1476-5411</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD9PwzAQxS0EolD4AgzII0uKndhOIrGgin9SJRaYLce5FJckbm0H1G-PoxRGljvr7r0n3w-hK0oWlFBxu1noVsEiJWk6DvKSHaEzynKRcEbpcXxnIk8IK9gMnXu_IdFUluQUzTLBacYFP0PV0nbbIahgbK9arGLZe-OxbbCDYMaZ6dQa8G5QrQl7_G3CB65N04CDPmBt-6B0wC30HtfgzTp20-NPcCrYuB38BTppVOvh8tDn6P3x4W35nKxen16W96tEx6-EBHhWM6pZoUVGCuCUkJTkaSNiiQtRCw4lU4yLqilqQlTFG1JBnld5VWhVZXN0M-Vund0N4IPsjNfQtqoHO3iZ5pxxErPLKE0nqXbWeweN3Lp4pttLSuTIVm7kyFaObOXENpquD_lD1UH9Z_mFGQV3kwDilV8GnPTaQK-hNg50kLU1_-X_AIiQi6I</recordid><startdate>202304</startdate><enddate>202304</enddate><creator>Devi, Preetirupa</creator><creator>Kumar, Preetam</creator><creator>Bharadwaj, Shrikant R.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202304</creationdate><title>Computational analysis of retinal image quality with different contact lens designs in keratoconus</title><author>Devi, Preetirupa ; Kumar, Preetam ; Bharadwaj, Shrikant R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c356t-e53d41c48c6308e51002072f6072d416d65e94a456bf8d00ab5f0be77b7b8cab3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Coma</topic><topic>Contact lens</topic><topic>Contact Lenses</topic><topic>Humans</topic><topic>Image quality</topic><topic>Keratoconus</topic><topic>Keratoconus - therapy</topic><topic>Lens, Crystalline</topic><topic>Refraction, Ocular</topic><topic>Sensitivity analysis</topic><topic>Visual functions</topic><topic>Wavefront aberrations</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Devi, Preetirupa</creatorcontrib><creatorcontrib>Kumar, Preetam</creatorcontrib><creatorcontrib>Bharadwaj, Shrikant R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Contact lens & anterior eye</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Devi, Preetirupa</au><au>Kumar, Preetam</au><au>Bharadwaj, Shrikant R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Computational analysis of retinal image quality with different contact lens designs in keratoconus</atitle><jtitle>Contact lens & anterior eye</jtitle><addtitle>Cont Lens Anterior Eye</addtitle><date>2023-04</date><risdate>2023</risdate><volume>46</volume><issue>2</issue><spage>101794</spage><epage>101794</epage><pages>101794-101794</pages><artnum>101794</artnum><issn>1367-0484</issn><eissn>1476-5411</eissn><abstract>To determine 1) the relative differences in optical quality of keratoconic eyes fitted with four routinely used CL designs and 2) the Zernike coefficients in the residual wavefront aberration map that may be responsible for differences in the optical quality of keratoconic eyes fitted with these CLs.
Wavefront aberrations over a 3-mm pupil diameter were measured without and with Kerasoft IC®, Rose K2®, conventional spherical Rigid Gas Permeable (RGP), and Scleral CLs in 15 mild to moderate keratoconic eyes (20 – 28 years) and under unaided viewing in 10 age-similar non-contact lens wearing controls. The resultant through-focus curves constructed for the logarithm of Neural Sharpness (logNS) Image Quality (IQ) metric were quantified in terms of peak value, best focus, and depth of focus. Sensitivity analyses determined the impact of the residual Zernike coefficients of keratoconic eyes fitted with CLs on the IQ of controls at emmetropic refraction.
The peak IQ and depth of focus were similar with Rose K2®, conventional RGP, and Scleral CLs (p > 0.05, for all) but significantly better than Kerasoft IC® CLs (p < 0.01 for all). Best focus was similar across all four CLs (p > 0.2 for all). However, the IQ parameters of all the lenses remained significantly poorer than the controls (p < 0.01, for all). The IQ of the controls dropped to keratoconic levels with induced residual lower-order Zernike terms and 3rd-order coma across all lenses in the sensitivity analysis (p < 0.001).
IQ of keratoconic eyes remain suboptimal with routinely dispensed CL designs, largely due to residual lower-order aberrations and coma, all relative to the controls. The performance drop appears greater for the Kerasoft IC® CL relative to the other CL designs. These results may provide the optical basis for psychophysical spatial visual performance reported earlier across these four CL designs for keratoconus.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>36513565</pmid><doi>10.1016/j.clae.2022.101794</doi><tpages>1</tpages></addata></record> |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Coma Contact lens Contact Lenses Humans Image quality Keratoconus Keratoconus - therapy Lens, Crystalline Refraction, Ocular Sensitivity analysis Visual functions Wavefront aberrations |
| title | Computational analysis of retinal image quality with different contact lens designs in keratoconus |
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