Cushing’s syndrome in women: age-related differences in etiology and clinical picture

Objective To evaluate the clinical presentation, biochemical profile, and etiology of Cushing’s syndrome (CS) in women stratified by age. Methods Retrospective study of patients with CS, treated at Rabin Medical Center from 2000 to 2020, or Maccabi Healthcare Services in Israel from 2005 to 2017. Disease etiology, presentation and biochemical profile were compared according to age at diagnosis: ≤ 45, 46–64, or ≥ 65 years. Study was approved by the Ethics Review Boards of both facilities with waiver of consent. Results The cohort included 142 women (mean age, 46.0 ± 15.1 years):81 (57.0%) with Cushing’s disease (CD), and 61 (43.0%) with adrenal CS. Pituitary etiology was more common among women