A new 1,2-diketone physalin isolated from Physalis minima and TRAIL-resistance overcoming activity of physalins

A new 1,2-diketone physalin, physalin XII ( 1 ), and 13 known compounds were isolated from the methanol extract of Physalis minima whole plant collected in Thailand. Among them, five physalins ( 2 – 6 ) had tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance overcoming activit...

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Veröffentlicht in:	Journal of natural medicines 2023-03, Vol.77 (2), p.370-378
Hauptverfasser:	Manome, Teruhisa, Hara, Yasumasa, Ishibashi, Masami
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Apoptosis Bcl-2 protein Biomedical and Life Sciences Biomedicine c-FLIP protein Cell Line Cell Line, Tumor cell lines Complementary & Alternative Medicine FLIP protein Humans Ligands Medicinal Chemistry methanol necrosis neoplasm cells neoplasms Pharmacology/Toxicology Pharmacy Physalis Physalis minima Plant extracts Plant Sciences Thailand TRAIL protein Tumor Necrosis Factor-alpha Western blotting
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Beschreibung
Zusammenfassung:	A new 1,2-diketone physalin, physalin XII ( 1 ), and 13 known compounds were isolated from the methanol extract of Physalis minima whole plant collected in Thailand. Among them, five physalins ( 2 – 6 ) had tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-resistance overcoming activity, and physalin F ( 3 ) was the most active with an IC 50 value of 0.39 µM against human gastric adenocarcinoma cell line AGS in the presence of TRAIL (100 ng/mL). An investigation of the TRAIL-resistance overcoming activity of physalins using western blot analysis showed that 3 promoted TRAIL-induced apoptosis by suppressing anti-apoptotic proteins c-FLIP and Bcl-2.
ISSN:	1340-3443 1861-0293
DOI:	10.1007/s11418-022-01670-x