Inflammation and Performance Status: The Cornerstones of Prognosis in Advanced Cancer

In advanced cancer, although performance status (PS), systemic inflammatory response and nutritional status are known to have prognostic value, geographical variations and sociodemographic indexes may also impact survival. This study compares validated prognostic factors in two international cohorts and establishes a prognostic framework for treatment. Two international biobanks of patients (n=1.518) with advanced cancer were analyzed. Prognostic factors (Eastern Cooperative Oncology Group Performance Status [ECOG-PS], body mass index [BMI] and modified Glasgow Prognostic Score [mGPS]) were assessed. The relationship between these and survival was examined using Kaplan–Meier and Cox regression methods. According to multivariate analysis, in the European cohort the most highly predictive factors were BMI 28 kg/m2) to 44% (mGPS 2, BMI