Determining structures of polymeric molecules by vibrational circular dichroism (VCD) spectroscopy

Vibrational circular dichroism (VCD) spectroscopy was applied to polymeric systems, in particular to several synthetic chiral polymers and DNA oligomers. After outlining the beginnings of VCD in general and as applied to the targeted systems, the two topics are discussed using examples from our laboratory. A generally optimistic conclusion is reached at the end, tempered by realization of inherent shortcomings and remaining difficulties.