Primary Helicobacter pylori resistance to antimicrobials in the Brussels area in 2021

•We are pleased to submit the new version of the manuscript corrected accordingly with all the changes or edits highlighted in yellow.•The locally update data of Helicobacter pylori resistance to antimicrobials is an important tool for the management of infected patients. This manuscript summarizes current primary resistance of Helicobacter pylori to antibiotics in Brussels in 2021. Resistance rates were estimated at 18% for clarithromycin, 24% for levofloxacin, 52% for metronidazole, and 0% for amoxicillin and tetracycline. When compared to 2016, resistance rates remain stable, except an increase of 30% for metronidazole.