Corrigendum to “PFOS-induced thyroid hormone system disrupted rats display organ-specific changes in their transcriptomes” [Environ. Pollut. 305 (2022) 119340]

Corrigendum to “PFOS-induced thyroid hormone system disrupted rats display organ-specific changes in their transcriptomes” [Environ. Pollut. 305 (2022) 119340]

•PFOS exposure decrease T4, T3, rT3 and T1Ac in adult male rats.•PFOS reduces thyroid hormone concentrations without activating the HPT-axis.•PFOS alters gene expression in hypothalamus, pituitary, thyroid and liver.•PFOS dysregulates axon function and vesicle transport genes in hypothalamus.•Compro...

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Veröffentlicht in:Environmental pollution (1987) 2023-01, Vol.317, p.120709-120709, Article 120709
Hauptverfasser: Davidsen, Nichlas, Ramhøj, Louise, Lykkebo, Claus Asger, Kugathas, Indusha, Poulsen, Rikke, Rosenmai, Anna Kjerstine, Evrard, Bertrand, Darde, Thomas A., Axelstad, Marta, Bahl, Martin Iain, Hansen, Martin, Chalmel, Frederic, Licht, Tine Rask, Svingen, Terje
Format: Artikel
Sprache:eng
Schlagworte:
Endocrine disrupting chemicals
HPT-Axis
Perfluoroalkyl
Perfluorooctane sulfonate
PFAS
PFOS
Thyroid
Thyroid hormone
Transcriptomics
Vancomycin
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Zusammenfassung:•PFOS exposure decrease T4, T3, rT3 and T1Ac in adult male rats.•PFOS reduces thyroid hormone concentrations without activating the HPT-axis.•PFOS alters gene expression in hypothalamus, pituitary, thyroid and liver.•PFOS dysregulates axon function and vesicle transport genes in hypothalamus.•Compromised gut microbiome had no significant effect on PFOS-induced DEGs.
ISSN:0269-7491
1873-6424
DOI:10.1016/j.envpol.2022.120709