LHPP, a risk factor for major depressive disorder, regulates stress-induced depression-like behaviors through its histidine phosphatase activity

Histidine phosphorylation (pHis), occurring on the histidine of substrate proteins, is a hidden phosphoproteome that is poorly characterized in mammals. LHPP (phospholysine phosphohistidine inorganic pyrophosphate phosphatase) is one of the histidine phosphatases and its encoding gene was recently i...

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Veröffentlicht in:	Molecular psychiatry 2023-02, Vol.28 (2), p.908-918
Hauptverfasser:	Lin, Dong, Li, Luhui, Chen, Wen-Bing, Chen, Jiang, Ren, Dongyan, Zheng, Zhi-Heng, Zhao, Changqin, Zhong, Yanzi, Luo, Bin, Jing, Hongyang, Chen, Peng, Zou, Suqi, Lai, Xinsheng, Zhou, Tian, Ding, Ning, Li, Lei, Pan, Bing-Xing, Fei, Erkang
Format:	Artikel
Sprache:	eng
Schlagworte:	13/1 13/106 13/109 631/378 64/60 692/699/476/1414 82/80 9/74 Animals Aspartic acid Behavioral Sciences Biological Psychology Depression Depressive Disorder, Major - metabolism Electrophysiology Glutamatergic transmission Histidine Histidine - metabolism Kinases Mammals - metabolism Medicine Medicine & Public Health Mental depression Mice Mice, Inbred C57BL Neurosciences Pharmacotherapy Phosphatase Phosphohistidine Phosphorylation Prefrontal cortex Prefrontal Cortex - metabolism Proteins - metabolism Psychiatry Risk Factors Social behavior Social interactions Stress, Psychological - metabolism Threonine
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