Maternal diet-induced inflammation alters fetal serotonin levels and offspring behavior
A maternal high-fat diet (mHFD) alters behavior in offspring in a sex-specific manner. We demonstrate that mHFD increases endotoxin levels in fetal tissues and decreases long-term serotonin bioavailability in male offspring owing to removal of serotonin neurons by microglia in the embryonic brain.
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| Veröffentlicht in: | Nature metabolism 2022-12, Vol.4 (12), p.1630-1631 |
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| container_title | Nature metabolism |
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| description | A maternal high-fat diet (mHFD) alters behavior in offspring in a sex-specific manner. We demonstrate that mHFD increases endotoxin levels in fetal tissues and decreases long-term serotonin bioavailability in male offspring owing to removal of serotonin neurons by microglia in the embryonic brain. |
| doi_str_mv | 10.1038/s42255-022-00696-5 |
| format | Article |
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| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | 631/250/371 631/378 Biomedical and Life Sciences Diet Humans Inflammation Life Sciences Research Briefing Serotonin |
| title | Maternal diet-induced inflammation alters fetal serotonin levels and offspring behavior |
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