Maternal diet-induced inflammation alters fetal serotonin levels and offspring behavior

Maternal diet-induced inflammation alters fetal serotonin levels and offspring behavior

A maternal high-fat diet (mHFD) alters behavior in offspring in a sex-specific manner. We demonstrate that mHFD increases endotoxin levels in fetal tissues and decreases long-term serotonin bioavailability in male offspring owing to removal of serotonin neurons by microglia in the embryonic brain.

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Veröffentlicht in:Nature metabolism 2022-12, Vol.4 (12), p.1630-1631
Format: Artikel
Sprache:eng
Schlagworte:
631/250/371
631/378
Biomedical and Life Sciences
Diet
Humans
Inflammation
Life Sciences
Research Briefing
Serotonin
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Zusammenfassung:A maternal high-fat diet (mHFD) alters behavior in offspring in a sex-specific manner. We demonstrate that mHFD increases endotoxin levels in fetal tissues and decreases long-term serotonin bioavailability in male offspring owing to removal of serotonin neurons by microglia in the embryonic brain.
ISSN:2522-5812
2522-5812
DOI:10.1038/s42255-022-00696-5