T1 relaxation of bound and pore water in cortical bone
MRI measures of bound and/or pore water concentration in cortical bone offer potential diagnostics of bone fracture risk. The transverse relaxation characteristics of both bound and pore water are relatively well understood and have been used to design clinical MRI pulse sequences to image each wate...
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| Veröffentlicht in: | NMR in biomedicine 2023-05, Vol.36 (5), p.e4878-n/a |
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| creator | Ketsiri, Thammathida Uppuganti, Sasidhar Harkins, Kevin D. Gochberg, Daniel F. Nyman, Jeffry S. Does, Mark D. |
| description | MRI measures of bound and/or pore water concentration in cortical bone offer potential diagnostics of bone fracture risk. The transverse relaxation characteristics of both bound and pore water are relatively well understood and have been used to design clinical MRI pulse sequences to image each water pool quantitatively. However, these methods are also sensitive to longitudinal relaxation characteristics, which have been less well studied. Here, spectroscopic relaxometry measurements of 31 human cortical bone specimens provided a more detailed picture of
T1 of both bound and pore water. The results included mean, standard deviation, and range of
T1 spectra from both bound and pore water, as well as novel presentations of the 2D
T1−T2 distribution of pore water. Importantly, for each sample the pore water
T1 spectrum was found to span more than one order of magnitude and varied substantially across the 31 sample studies. Because many existing methods assume pore water
T1 to be mono‐exponential and constant across individuals, the results were used to compute the potential effect neglecting this intra‐ and intersample
T1 variation on accurate MRI measurement of both bound and pore water concentrations. The greatest effect was found for adiabatic inversion recovery (AIR) based measurements of bound water concentration, which showed an average of 8.8% and as much as 37% error when using a common mono‐exponential assumption of pore water
T1. Despite these errors, the simulated AIR measurements were still moderately well correlated with the bound water concentrations derived from the spectroscopic data.
Spectroscopic relaxometry of 31 human cortical bone specimens provided a detailed picture of longitudinal relaxation of both the bound and porew water signal components. This figure show one‐dimensional presentations of the mean, standard deviation (SD), and range across samples of the bound and pore water
T1 spectra. The bound water
T1 is narrowly distributed and highly reproducible across individuals, while the pore water
T1 varies widely within and across individuals. |
| doi_str_mv | 10.1002/nbm.4878 |
| format | Article |
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T1 of both bound and pore water. The results included mean, standard deviation, and range of
T1 spectra from both bound and pore water, as well as novel presentations of the 2D
T1−T2 distribution of pore water. Importantly, for each sample the pore water
T1 spectrum was found to span more than one order of magnitude and varied substantially across the 31 sample studies. Because many existing methods assume pore water
T1 to be mono‐exponential and constant across individuals, the results were used to compute the potential effect neglecting this intra‐ and intersample
T1 variation on accurate MRI measurement of both bound and pore water concentrations. The greatest effect was found for adiabatic inversion recovery (AIR) based measurements of bound water concentration, which showed an average of 8.8% and as much as 37% error when using a common mono‐exponential assumption of pore water
T1. Despite these errors, the simulated AIR measurements were still moderately well correlated with the bound water concentrations derived from the spectroscopic data.
Spectroscopic relaxometry of 31 human cortical bone specimens provided a detailed picture of longitudinal relaxation of both the bound and porew water signal components. This figure show one‐dimensional presentations of the mean, standard deviation (SD), and range across samples of the bound and pore water
T1 spectra. The bound water
T1 is narrowly distributed and highly reproducible across individuals, while the pore water
T1 varies widely within and across individuals.</description><identifier>ISSN: 0952-3480</identifier><identifier>EISSN: 1099-1492</identifier><identifier>DOI: 10.1002/nbm.4878</identifier><language>eng</language><publisher>Oxford: Wiley Subscription Services, Inc</publisher><subject>Adiabatic ; Biological products ; bone ; Bound water ; Cortical bone ; Magnetic resonance imaging ; NMR ; Pore water ; relaxometry</subject><ispartof>NMR in biomedicine, 2023-05, Vol.36 (5), p.e4878-n/a</ispartof><rights>2022 John Wiley & Sons Ltd.</rights><rights>2023 John Wiley & Sons, Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-3708-1310 ; 0000-0003-2701-6208</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fnbm.4878$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fnbm.4878$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids></links><search><creatorcontrib>Ketsiri, Thammathida</creatorcontrib><creatorcontrib>Uppuganti, Sasidhar</creatorcontrib><creatorcontrib>Harkins, Kevin D.</creatorcontrib><creatorcontrib>Gochberg, Daniel F.</creatorcontrib><creatorcontrib>Nyman, Jeffry S.</creatorcontrib><creatorcontrib>Does, Mark D.</creatorcontrib><title>T1 relaxation of bound and pore water in cortical bone</title><title>NMR in biomedicine</title><description>MRI measures of bound and/or pore water concentration in cortical bone offer potential diagnostics of bone fracture risk. The transverse relaxation characteristics of both bound and pore water are relatively well understood and have been used to design clinical MRI pulse sequences to image each water pool quantitatively. However, these methods are also sensitive to longitudinal relaxation characteristics, which have been less well studied. Here, spectroscopic relaxometry measurements of 31 human cortical bone specimens provided a more detailed picture of
T1 of both bound and pore water. The results included mean, standard deviation, and range of
T1 spectra from both bound and pore water, as well as novel presentations of the 2D
T1−T2 distribution of pore water. Importantly, for each sample the pore water
T1 spectrum was found to span more than one order of magnitude and varied substantially across the 31 sample studies. Because many existing methods assume pore water
T1 to be mono‐exponential and constant across individuals, the results were used to compute the potential effect neglecting this intra‐ and intersample
T1 variation on accurate MRI measurement of both bound and pore water concentrations. The greatest effect was found for adiabatic inversion recovery (AIR) based measurements of bound water concentration, which showed an average of 8.8% and as much as 37% error when using a common mono‐exponential assumption of pore water
T1. Despite these errors, the simulated AIR measurements were still moderately well correlated with the bound water concentrations derived from the spectroscopic data.
Spectroscopic relaxometry of 31 human cortical bone specimens provided a detailed picture of longitudinal relaxation of both the bound and porew water signal components. This figure show one‐dimensional presentations of the mean, standard deviation (SD), and range across samples of the bound and pore water
T1 spectra. The bound water
T1 is narrowly distributed and highly reproducible across individuals, while the pore water
T1 varies widely within and across individuals.</description><subject>Adiabatic</subject><subject>Biological products</subject><subject>bone</subject><subject>Bound water</subject><subject>Cortical bone</subject><subject>Magnetic resonance imaging</subject><subject>NMR</subject><subject>Pore water</subject><subject>relaxometry</subject><issn>0952-3480</issn><issn>1099-1492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><recordid>eNpdkE1LAzEURYMoWKvgTwi4cTP15aMzyVKLVaHqpq7DS5qBKdNkzMxQ--9NqSsXj7t4h8vlEHLLYMYA-EOwu5lUlTojEwZaF0xqfk4moOe8EFLBJbnq-y0AKCn4hJRrRpNv8QeHJgYaa2rjGDYU83UxebrHwSfaBOpiGhqHbQaCvyYXNba9v_nLKflaPq8Xr8Xq8-Vt8bgqOj6XqmDWITpWSl2XTgrLN7V1c4Ub8EJKi8xD_mghVIU1ltY56Tx4K6WvsBQopuT-1Nul-D36fjC7pne-bTH4OPaGV0JXUgpWZvTuH7qNYwp5neEKQGjNmc5UcaL2TesPpkvNDtPBMDBHeybbM0d75uPp_ZjiF5pvYug</recordid><startdate>202305</startdate><enddate>202305</enddate><creator>Ketsiri, Thammathida</creator><creator>Uppuganti, Sasidhar</creator><creator>Harkins, Kevin D.</creator><creator>Gochberg, Daniel F.</creator><creator>Nyman, Jeffry S.</creator><creator>Does, Mark D.</creator><general>Wiley Subscription Services, Inc</general><scope>7QO</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-3708-1310</orcidid><orcidid>https://orcid.org/0000-0003-2701-6208</orcidid></search><sort><creationdate>202305</creationdate><title>T1 relaxation of bound and pore water in cortical bone</title><author>Ketsiri, Thammathida ; Uppuganti, Sasidhar ; Harkins, Kevin D. ; Gochberg, Daniel F. ; Nyman, Jeffry S. ; Does, Mark D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p2548-1bcaac1649f6c43b2dfbc58ad0e344ba1e09f693387afa6bcc4ce0eb44e7a63a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2023</creationdate><topic>Adiabatic</topic><topic>Biological products</topic><topic>bone</topic><topic>Bound water</topic><topic>Cortical bone</topic><topic>Magnetic resonance imaging</topic><topic>NMR</topic><topic>Pore water</topic><topic>relaxometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ketsiri, Thammathida</creatorcontrib><creatorcontrib>Uppuganti, Sasidhar</creatorcontrib><creatorcontrib>Harkins, Kevin D.</creatorcontrib><creatorcontrib>Gochberg, Daniel F.</creatorcontrib><creatorcontrib>Nyman, Jeffry S.</creatorcontrib><creatorcontrib>Does, Mark D.</creatorcontrib><collection>Biotechnology Research Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>NMR in biomedicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ketsiri, Thammathida</au><au>Uppuganti, Sasidhar</au><au>Harkins, Kevin D.</au><au>Gochberg, Daniel F.</au><au>Nyman, Jeffry S.</au><au>Does, Mark D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>T1 relaxation of bound and pore water in cortical bone</atitle><jtitle>NMR in biomedicine</jtitle><date>2023-05</date><risdate>2023</risdate><volume>36</volume><issue>5</issue><spage>e4878</spage><epage>n/a</epage><pages>e4878-n/a</pages><issn>0952-3480</issn><eissn>1099-1492</eissn><abstract>MRI measures of bound and/or pore water concentration in cortical bone offer potential diagnostics of bone fracture risk. The transverse relaxation characteristics of both bound and pore water are relatively well understood and have been used to design clinical MRI pulse sequences to image each water pool quantitatively. However, these methods are also sensitive to longitudinal relaxation characteristics, which have been less well studied. Here, spectroscopic relaxometry measurements of 31 human cortical bone specimens provided a more detailed picture of
T1 of both bound and pore water. The results included mean, standard deviation, and range of
T1 spectra from both bound and pore water, as well as novel presentations of the 2D
T1−T2 distribution of pore water. Importantly, for each sample the pore water
T1 spectrum was found to span more than one order of magnitude and varied substantially across the 31 sample studies. Because many existing methods assume pore water
T1 to be mono‐exponential and constant across individuals, the results were used to compute the potential effect neglecting this intra‐ and intersample
T1 variation on accurate MRI measurement of both bound and pore water concentrations. The greatest effect was found for adiabatic inversion recovery (AIR) based measurements of bound water concentration, which showed an average of 8.8% and as much as 37% error when using a common mono‐exponential assumption of pore water
T1. Despite these errors, the simulated AIR measurements were still moderately well correlated with the bound water concentrations derived from the spectroscopic data.
Spectroscopic relaxometry of 31 human cortical bone specimens provided a detailed picture of longitudinal relaxation of both the bound and porew water signal components. This figure show one‐dimensional presentations of the mean, standard deviation (SD), and range across samples of the bound and pore water
T1 spectra. The bound water
T1 is narrowly distributed and highly reproducible across individuals, while the pore water
T1 varies widely within and across individuals.</abstract><cop>Oxford</cop><pub>Wiley Subscription Services, Inc</pub><doi>10.1002/nbm.4878</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0003-3708-1310</orcidid><orcidid>https://orcid.org/0000-0003-2701-6208</orcidid></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | Adiabatic Biological products bone Bound water Cortical bone Magnetic resonance imaging NMR Pore water relaxometry |
| title | T1 relaxation of bound and pore water in cortical bone |
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