1H‐1,2,3‐Triazole−4H‐chromene−D‐glucose hybrid compounds: Synthesis and inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B

A series of 1H‐1,2,3‐triazole−4H‐chromene−D‐glucose hybrid compounds 7a–w were synthesized using click chemistry of 2‐amino‐7‐propargyloxy‐4H‐chromene‐3‐carbonitriles 5a–w. CuNPs@montmorillonite was used as a catalyst in the presence of DIPEA as an additive for this chemistry. All synthesized 1H‐1,2,3‐triazoles were examined for in vitro inhibition against Mycobacterium tuberculosis protein tyrosine phosphatase B (MtbPtpB). Nine 1H‐1,2,3‐triazoles, including 7c–e, 7h, 7i, and 7r–t, displayed remarkable inhibitory activity against MtbPtpB with IC50