Assessing Antigen-Adjuvant Complex Stability Against Physical Stresses By wNMR

This study applies an emerging analytical technology, w NMR (water proton nuclear magnetic resonance), to assess the stability of aluminum adjuvants and antigen-adjuvant complexes against physical stresses, including gravitation, flow and freeze/thaw. Results from w NMR are verified by conventional...

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Veröffentlicht in:	Pharmaceutical research 2023-06, Vol.40 (6), p.1435-1446
Hauptverfasser:	Taraban, Marc B., Briggs, Katharine T., Yu, Yihua Bruce, Jones, Michael T., Rosner, Lindsey, Bhambhani, Akhilesh, Williams, Donna M., Farrell, Christopher, Reibarkh, Mikhail, Su, Yongchao
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Adjuvants, Immunologic - chemistry Aluminum Aluminum - chemistry Antigens Antigens - chemistry Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Collaboration Data collection Freeze-thawing Light scattering Medical Law Microfluidics NMR Nuclear magnetic resonance Original Research Article Particle size Pharmaceuticals Pharmacology/Toxicology Pharmacy Product development R&D Research & development Solvents Spectrum analysis Vaccines
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Beschreibung
Zusammenfassung:	This study applies an emerging analytical technology, w NMR (water proton nuclear magnetic resonance), to assess the stability of aluminum adjuvants and antigen-adjuvant complexes against physical stresses, including gravitation, flow and freeze/thaw. Results from w NMR are verified by conventional analytical technologies, including static light scattering and microfluidic imaging. The results show that w NMR can quickly and noninvasively determine whether an aluminum adjuvant or antigen-adjuvant complex sample has been altered by physical stresses.
ISSN:	0724-8741 1573-904X
DOI:	10.1007/s11095-022-03437-1