Effects of intra‐articular injection of an acellular equine liquid amniotic allograft in healthy equine joints

Objective Evaluate effects of acellular equine liquid amnion allograft (ELAA) injected into healthy equine joints. Study design Randomized, blinded, controlled experiment. Animals Eight healthy adult horses. Methods One intercarpal joint (ICJ) of each horse was randomly assigned to be injected with...

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Veröffentlicht in:Veterinary surgery 2023-01, Vol.52 (1), p.62-68
Hauptverfasser: Wolkowski, Danica D., McCarthy, Robert D., Schoonover, Mike J., Taylor, Jared D., Eastman, Timothy G.
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Sprache:eng
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Zusammenfassung:Objective Evaluate effects of acellular equine liquid amnion allograft (ELAA) injected into healthy equine joints. Study design Randomized, blinded, controlled experiment. Animals Eight healthy adult horses. Methods One intercarpal joint (ICJ) of each horse was randomly assigned to be injected with 1.5 ml of ELAA (treatment) while the contralateral ICJ was injected with 1.5 ml of 0.9% NaCl (control). Subjective lameness evaluation, force plate analysis, and synovial fluid analysis, including interleukin‐1 receptor antagonist (IL‐1ra) analysis, were performed before (day 0) and at days 1, 3, 5, and 10. Synovial fluid analysis was also performed on days 20 and 30. Results No difference in subjective lameness (P = .75) and no decrease in peak vertical force or vertical impulse were seen in any limb on any day. Total nucleated cell count (TNCC) was increased in treatment joints on days 1 (P = .0007; T: 6039 cells/μl, C: 240 cells/μl) and 3 (P 
ISSN:0161-3499
1532-950X
DOI:10.1111/vsu.13918