Endogenous retrovirus expression during fruitfly metamorphosis enhances adult viral immunity

The evolutionary benefits of ongoing endogenous retrovirus (ERV) mobility in animals are largely unknown. A new paradigm suggests activation of the ERV family mdg4 at the fruitfly pupal stage may bolster adult antiviral defenses.

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Bibliographische Detailangaben
Veröffentlicht in:	Nature genetics 2022-12, Vol.54 (12), p.1765-1767
Hauptverfasser:	Botto, Juan M., Faulkner, Geoffrey J.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/200 631/250/255 Agriculture Animal Genetics and Genomics Animals Biomedical and Life Sciences Biomedicine Cancer Research Drosophila Endogenous retroviruses Fat body Fluorescence Gene Function Gene sequencing Genomes Green fluorescent protein Hindgut Human Genetics Immune system Infections Insects Metamorphosis Metamorphosis, Biological - genetics Mortality Mutagenesis News & Views news-and-views Proteins Retrotransposition Reverse transcription RNA-mediated interference Viral infections Viruses
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Beschreibung
Zusammenfassung:	The evolutionary benefits of ongoing endogenous retrovirus (ERV) mobility in animals are largely unknown. A new paradigm suggests activation of the ERV family mdg4 at the fruitfly pupal stage may bolster adult antiviral defenses.
ISSN:	1061-4036 1546-1718
DOI:	10.1038/s41588-022-01209-6